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Database: UniProt
Entry: U1EWB9_9ACTN
LinkDB: U1EWB9_9ACTN
Original site: U1EWB9_9ACTN 
ID   U1EWB9_9ACTN            Unreviewed;       648 AA.
AC   U1EWB9;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   16-JAN-2019, entry version 26.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=H641_07040 {ECO:0000313|EMBL:ERF56017.1};
OS   Cutibacterium granulosum DSM 20700.
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=1160719 {ECO:0000313|EMBL:ERF56017.1, ECO:0000313|Proteomes:UP000016307};
RN   [1] {ECO:0000313|EMBL:ERF56017.1, ECO:0000313|Proteomes:UP000016307}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20700 {ECO:0000313|EMBL:ERF56017.1,
RC   ECO:0000313|Proteomes:UP000016307};
RX   PubMed=24053623; DOI=10.1186/1471-2164-14-640;
RA   Mak T.N., Schmid M., Brzuszkiewicz E., Zeng G., Meyer R., Sfanos K.S.,
RA   Brinkmann V., Meyer T.F., Bruggemann H.;
RT   "Comparative genomics reveals distinct host-interacting traits of
RT   three major human-associated propionibacteria.";
RL   BMC Genomics 14:640-640(2013).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERF56017.1}.
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DR   EMBL; AOSS01000265; ERF56017.1; -; Genomic_DNA.
DR   EnsemblBacteria; ERF56017; ERF56017; H641_07040.
DR   PATRIC; fig|1160719.4.peg.1323; -.
DR   Proteomes; UP000016307; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016307};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016307};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    229    252       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    272    293       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    300    321       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    333    351       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    363    391       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    403    423       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    462    481       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    593    612       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    624    647       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN       15    182       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   648 AA;  69165 MW;  5A17CD3BB406089A CRC64;
     MTCHSPATEQ APDGATRIAL IGSPNGGKTS IFNQLTGLHA KTGNYPGVTV SRSEGVARIH
     DHTFAIEDLP GTYSLSPISP DEQVVVDVLD GRMDQVSAPD ALVVVADATA LRRSLLLLAE
     VLPRHLPTAV VVTMTDELRR RQGSLDVTAL SQALGVPVVA VVANRGIGIG ELRNLLTTWH
     DWDRPPLDPP GRSSELAGWV DSVLDTAGYE DPDPDSRTER IDKVLLHPVW GTIVFFAVMF
     LFFQALFAWA APLQDAVDEF FGWLASLVGE HVGNPILASL LGDGILGGVG AVLTFVPQIL
     LMYLLLALLD AVGYMSRAAF LMDKVMSRAG LEGRAFVAML SSFACAIPGI MATRTIPSAK
     DRIATMLSAP LATCSARLPV YVLLVGILVP AGSSLGPVSV RGLVLFGMYL LGALSAMLAA
     RVVKKITDRS GTLLPFYMEM PPYRIPTPRS VGMAMWEPTK AFLRKAGTII MGATIVIWAL
     TTFPLRSDAE MTAAGVDPSD EVAATAYNME HSAAAKVGKA IEPVFAPQGF DWRVNISLIG
     SMAAREVAVS TLGQVASASD PEDDVSVSES VQKWTYTDGP HQGEKVFTPD TTIAMLIFFA
     FALQCVATIG ILKRESGGWK WPAIAFGYMF VLAWVGSSLA AIITRAVM
//
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