ID   U1FAV4_TRESO            Unreviewed;      1519 AA.
AC   U1FAV4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=2-hydroxyglutaryl-CoA dehydratase, D-component {ECO:0000313|EMBL:ERF61282.1};
DE            EC=4.2.1.- {ECO:0000313|EMBL:ERF61282.1};
GN   ORFNames=HMPREF1325_1939 {ECO:0000313|EMBL:ERF61282.1};
OS   Treponema socranskii subsp. socranskii VPI DR56BR1116 = ATCC 35536.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=1125725 {ECO:0000313|EMBL:ERF61282.1, ECO:0000313|Proteomes:UP000016412};
RN   [1] {ECO:0000313|EMBL:ERF61282.1, ECO:0000313|Proteomes:UP000016412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VPI DR56BR1116 {ECO:0000313|EMBL:ERF61282.1,
RC   ECO:0000313|Proteomes:UP000016412};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA   Methe B., Sutton G., Nelson K.E.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERF61282.1}.
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DR   EMBL; AUZJ01000014; ERF61282.1; -; Genomic_DNA.
DR   RefSeq; WP_021329826.1; NZ_AUZJ01000014.1.
DR   STRING; 1125725.HMPREF1325_1939; -.
DR   PATRIC; fig|1125725.3.peg.751; -.
DR   eggNOG; COG1924; Bacteria.
DR   eggNOG; COG3580; Bacteria.
DR   eggNOG; COG3581; Bacteria.
DR   OrthoDB; 9802715at2; -.
DR   Proteomes; UP000016412; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:ERF61282.1}.
FT   DOMAIN          17..270
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          346..600
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          731..952
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1519 AA;  168146 MW;  0C4289046C42A85E CRC64;
     MAVTQSALHN ELLPIRIGID VGSTTVKIAV LDDDDTLIYS DYERHRADIR STIISVVNKA
     LDFLEKNIAG GAERAVTVKV TGSGGLSVSQ WLSVPFIQEV IAATTAVKTI IPLTDVVIEL
     GGEDAKITYF KGGVEQRMNG TCAGGTGAFI DQMAALLETD ADGLNTLAKD AHTIYPIAAR
     CGVFAKTDVQ PLINEGARRE DIAASIFQAV VNQTISGLAC GKPIRGHVAF LGGPLHFMDQ
     LRERFIVTLK LKDDEIIVPE NSQLFVAQGC AYSADRRYSG MPDFIFPTVA DFRSSLSNLV
     GAELSEVQRL EPLFKSQSDL DEFVSRHAKE KAKRGDLDSV KGPVFLGLDA GSTTTKAVLI
     DQEGRILWDF YAANAGNPVD LAVKVLKGLY ARLPKDVYIA RAVSTGYGEA LFQAALNVDA
     GEVETITHFR AADFFVPGVE FLLDIGGQDM KCLRMKDGAI VSIQLNEACS SGCGSFLDNF
     ARTMGMDVRE FSKRALRAEK PVDLGSRCTV FMNSRVKQAQ KEGASVADIS AGLSYSVIKN
     ALFKVIKLRK ASDIGTKVVV QGGTFNNDAV LRAFENISGV HVFRPDVAGL MGAYGSALIA
     YDQWLDLSAP KPEEGPGAPR HEIRSGIATL SDLESFSVKL DLRRCGKCQN NCLLTINTFS
     TGGFERKFVT GNRCERGAEL DGNVLDASNK KATNIEAGKE GKLPNMFAWK YARLFNNYIP
     LRAEDAPMGE VGIPRVLNMY ENYPLWFTFF TALGFRVRLS SRSSRTVYEK GLETIPSESV
     CYPGKISHGH VESLLQQGVK FIFYPCAPYE LQEDSTAGNH YNCPIVTSYP EVLRNNIDSL
     RQDASILYMD PFLPIYDKDR LAVRLAEELI PHFPELTKER ISRAVDEAWK EEEKFRRDTE
     EKGIEAIEET IRRGANGIVL AGRPYHLDPE INHGIPELIN DLGLAVFTED SVAHLGSIER
     PLRIIDQWTY HNRLYRAASF VTGMPNIELV QLTSFGCGLD AVTADQVDEI MRAKGRMYTL
     IKIDEGANLG AVRIRIRSLI AAVKERERRH QKPVVKSASY RKQVFTKEMK YTHTIIAPQM
     SPIHFRLFQK AFEYSGYKFV VLDAVDPRAV DIGLRFVNND ACYPSILVTG QMIAALESGK
     YDLNHTSLII SQTGGGCRAT NYIGFIRRAL NDAGWGHIPV LSLNANGLEQ NPGFKVTLPL
     LERLIMSSMI GDVLMRVLYR TRPYEKVQGS ANALYEKWNG RAEIQLRSLS VRGFHKLVKN
     IIDDFDALPL LPIKKPRIGI VGEILVKFHP TANNQIVDTI EREGAEAVMP DMVNFFLYTF
     STGIFRHEKL AFPKKTETIA RLLVWFTERF RKPIEKYLRK SRRFDAPETI YEQMKSVDDI
     VQLGNITGEG WFLTAEMVEL IKTGVPSIAC VQPFACLPNH VTGKGMIKEL RRRFPGANIS
     AIDYDPGSSE VNQLNRLKLL LSNAPIGKHP DENEDGMIVM SDDSLVKPEI RFAEGAVSFT
     DFEPVAAGNR PPVLAPVHA
//