ID U1FCV7_9ACTN Unreviewed; 362 AA.
AC U1FCV7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245};
DE AltName: Full=Membrane protein YidC {ECO:0000256|ARBA:ARBA00031538};
GN ORFNames=H641_03103 {ECO:0000313|EMBL:ERF57433.1}, L860_06165
GN {ECO:0000313|EMBL:OCT43084.1};
OS Cutibacterium granulosum DSM 20700.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium.
OX NCBI_TaxID=1160719 {ECO:0000313|EMBL:ERF57433.1, ECO:0000313|Proteomes:UP000016307};
RN [1] {ECO:0000313|EMBL:ERF57433.1, ECO:0000313|Proteomes:UP000016307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20700 {ECO:0000313|EMBL:ERF57433.1,
RC ECO:0000313|Proteomes:UP000016307};
RX PubMed=24053623; DOI=10.1186/1471-2164-14-640;
RA Mak T.N., Schmid M., Brzuszkiewicz E., Zeng G., Meyer R., Sfanos K.S.,
RA Brinkmann V., Meyer T.F., Bruggemann H.;
RT "Comparative genomics reveals distinct host-interacting traits of three
RT major human-associated propionibacteria.";
RL BMC Genomics 14:640-640(2013).
RN [2] {ECO:0000313|EMBL:OCT43084.1, ECO:0000313|Proteomes:UP000094467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20700 {ECO:0000313|EMBL:OCT43084.1,
RC ECO:0000313|Proteomes:UP000094467};
RA Jahns A.C., Eilers H., Alexeyev O.A.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|ARBA:ARBA00025034}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration.
CC {ECO:0000256|ARBA:ARBA00026028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERF57433.1}.
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DR EMBL; AOSS01000098; ERF57433.1; -; Genomic_DNA.
DR EMBL; JNBU01000004; OCT43084.1; -; Genomic_DNA.
DR RefSeq; WP_021103639.1; NZ_AOSS01000098.1.
DR AlphaFoldDB; U1FCV7; -.
DR GeneID; 85154863; -.
DR PATRIC; fig|1160719.4.peg.595; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000016307; Unassembled WGS sequence.
DR Proteomes; UP000094467; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000016307};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..266
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 282..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40852 MW; 9F3EC784771BB5C9 CRC64;
MLNPLVIMLG LGDGFHAIGH AIMLPLYWAV SGLVVLFHAM WSPVFGSDSG ATWTLAIITL
TIFIRILLIP LFVKQINSAR AMQLIQPKMK AIQDKYGDDR QRAGQEMMNL YKEEGVNPAA
SCLPILLQMP IFLALFRVLD GASRGTPRGH FFVDHPELVA SLQHARFFGA ELAGRFLPMT
NGFGGTQIVA LVLIIIMVVT LFYTQMQLMR KNMPPEALTG PMAQQQKMMI YLFPLMYLFS
GVSFPIGVMI YWATSNLWTL GQQEILIRNN PTPNTPAYID WQERMRAKGK DPDEIERQRR
EKRRRKVVSA TPTPAGDPSD AARPAVARQQ VTRQTVRKDA NGNKQVVRRQ QPARQSRSKR
KH
//
