ID U1FJV8_TRESO Unreviewed; 796 AA.
AC U1FJV8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=MMPL family protein {ECO:0000313|EMBL:ERF60083.1};
GN ORFNames=HMPREF1325_0433 {ECO:0000313|EMBL:ERF60083.1};
OS Treponema socranskii subsp. socranskii VPI DR56BR1116 = ATCC 35536.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=1125725 {ECO:0000313|EMBL:ERF60083.1, ECO:0000313|Proteomes:UP000016412};
RN [1] {ECO:0000313|EMBL:ERF60083.1, ECO:0000313|Proteomes:UP000016412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VPI DR56BR1116 {ECO:0000313|EMBL:ERF60083.1,
RC ECO:0000313|Proteomes:UP000016412};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERF60083.1}.
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DR EMBL; AUZJ01000049; ERF60083.1; -; Genomic_DNA.
DR RefSeq; WP_021330940.1; NZ_AVQI01000079.1.
DR AlphaFoldDB; U1FJV8; -.
DR STRING; 1125725.HMPREF1325_0433; -.
DR PATRIC; fig|1125725.3.peg.1959; -.
DR eggNOG; COG1033; Bacteria.
DR OrthoDB; 9794724at2; -.
DR Proteomes; UP000016412; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 257..388
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 655..781
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 796 AA; 89339 MW; 2D2ED13F1D259F17 CRC64;
MKVLEINKAF RKFGEIQVKF RWLFLLAMFV VTAVGLSGLR KFVAEDLQED WFGDKEKIKL
ATDRFEETFG NEDVITVLVQ TKDVFDSDVL NMIDRLGNEM METIPYARDV MSVVEVSVAK
GTDDGMQVVT PFEDGIPDTH TAEGKAEMES IKKFLLSREA IANKLVSEDA TETWVILYLY
GYGEEDNKAR TGMYKAGRAA HKLLEDPKWQ SDKWNLICAG TPYTECEETD VMQKEMSRNL
ISGFIAMIIC LILFVRSLRG LIVPLFSTVG GIGVVFGFMS YFGIVADQNM MTIPILLGMA
LSVGYSIHYI NSFKLHFRQT GIRKESVIMS VEETGWPLFF TALTTIASLI SFALVDIGPL
KWLGLTSSAT VLVIFLYAII LIPVLLSFGK DKKKEESATT QKVTKADLAF ESFGKRVLKH
SKAVLIVGFA MIVVFIPGIF KIRVTLDYIE MLGLKIPYIA RLAKLQETQL GSVYSYKILI
EYPDVDEFKK PERMFALEKL ENTLGNLSLT RKSNGKPRVK SVLDIVKETN RMLNGDDPAY
YSIPDDEDLL TQELFLYEIT GGSRLYDWLN ADYNMAYVNV NLATYNSSQI ASNIADAEKA
AEELFPGAEV SAIGAVAEFA EMNGKIVRGE LKSFAGSFIM IAAMLILVFM SIRTGLIGMI
PNITPVIILA GIMGYFRFQL DMMTMTIMPM ILGIAVDDTI HFINHVKYYY EVHGNYKDAI
LRTYLEIGKT MCMTTVIICA MFLIYAFSPM TTMHRIGMLS IIGLTAALVA DYLMTPALIY
VTKPFGKEFD GIERNR
//
