ID U1G9X3_ENDPU Unreviewed; 423 AA.
AC U1G9X3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=EPUS_05630 {ECO:0000313|EMBL:ERF68491.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF68491.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KE721517; ERF68491.1; -; Genomic_DNA.
DR RefSeq; XP_007805842.1; XM_007807651.1.
DR AlphaFoldDB; U1G9X3; -.
DR GeneID; 19240578; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; TACARYY; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT DOMAIN 74..328
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 423 AA; 46667 MW; F0A87F14955DD752 CRC64;
MAPDSSAPIV LGRVLIVGGC GFLGYHVVDQ FLNFASEEDL PLPKPATSTR TSKPDAASFE
FPTLRSRYPL YAKTEVHVLD LRCNRNRLPG ATYHEGDLCD PASLLPVFRE VKPQVVINTA
SPTYDAPREI LRKVNIEGTK TLLEVAGGAH GDWGGKCKAF VHTSSSSVVH DCLNDLINAD
ERWPLVRPHP VEYYTESKAD AEEIVLEANK KHNDMLTCAI RPAGIVGERD RAGMTDALLQ
TAAHAPDWQL HFQFGEGNNL FDCTYVGNVA YGLAVAAEAL LHTSARIAAG EAVPLDHEKV
DGEAFIVTND SPAYFWDIAR YVWTLYGRTV SMSKVWQLSK GFLLPVGALA EMSTYITGKK
TKMTRQSIRY ATMQRYFNCD KLKRRCGYTP LVGLEEGLAR AVKSFVLSER AEKEALGGEK
KVQ
//
