ID U1GAG4_9ACTN Unreviewed; 424 AA.
AC U1GAG4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=H641_08812 {ECO:0000313|EMBL:ERF55330.1}, L860_11295
GN {ECO:0000313|EMBL:OCT42252.1};
OS Cutibacterium granulosum DSM 20700.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium.
OX NCBI_TaxID=1160719 {ECO:0000313|EMBL:ERF55330.1, ECO:0000313|Proteomes:UP000016307};
RN [1] {ECO:0000313|EMBL:ERF55330.1, ECO:0000313|Proteomes:UP000016307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20700 {ECO:0000313|EMBL:ERF55330.1,
RC ECO:0000313|Proteomes:UP000016307};
RX PubMed=24053623; DOI=10.1186/1471-2164-14-640;
RA Mak T.N., Schmid M., Brzuszkiewicz E., Zeng G., Meyer R., Sfanos K.S.,
RA Brinkmann V., Meyer T.F., Bruggemann H.;
RT "Comparative genomics reveals distinct host-interacting traits of three
RT major human-associated propionibacteria.";
RL BMC Genomics 14:640-640(2013).
RN [2] {ECO:0000313|EMBL:OCT42252.1, ECO:0000313|Proteomes:UP000094467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20700 {ECO:0000313|EMBL:OCT42252.1,
RC ECO:0000313|Proteomes:UP000094467};
RA Jahns A.C., Eilers H., Alexeyev O.A.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERF55330.1}.
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DR EMBL; AOSS01000329; ERF55330.1; -; Genomic_DNA.
DR EMBL; JNBU01000032; OCT42252.1; -; Genomic_DNA.
DR RefSeq; WP_021104762.1; NZ_AOSS01000329.1.
DR AlphaFoldDB; U1GAG4; -.
DR PATRIC; fig|1160719.4.peg.1669; -.
DR OrthoDB; 7345302at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000016307; Unassembled WGS sequence.
DR Proteomes; UP000094467; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03414; CbiX_SirB_C; 1.
DR CDD; cd03416; CbiX_SirB_N; 1.
DR Gene3D; 3.40.50.1400; -; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002762; CbiX-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR33542:SF5; FERROCHELATASE CHE1; 1.
DR PANTHER; PTHR33542; SIROHYDROCHLORIN FERROCHELATASE, CHLOROPLASTIC; 1.
DR Pfam; PF01903; CbiX; 2.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF53800; Chelatase; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016307}.
SQ SEQUENCE 424 AA; 45448 MW; 46B077B46119150D CRC64;
MTDTKIASGT PLVIAAHGTR DESGVAECRA LAERVANKLP DVPVELGFVE LAEPKIPEAV
QAAVAQAPGV SEEPTEGEQS VSAVVVPLMF NTGGHVREDI PEAIDEGRGG ARVAYSAPLL
PDVRMRKALD RRLAETLAAG EGREQWRARD TAVVLVGRGA LVADANASHY TLTRMFWEEN
DLACVEPAFI QVTRPSVPEA LTALHARGAQ QIVVQGNFLF PGLLHVWMTE QVQAWQASHP
GVEIRIAPVI GDCDEVAEVV VDRYREPLDE VGLGEGAPVY MSGLRLQGRT VLVVGAGHVA
ERRVARLLDA GADVHVVAPN SGIQLTRMAR KGLVNLERRA FQTDDLDGVW FVQALTNDPQ
VNATVAAEAE KRGIFCVRGD DGRKGSAFTP ATQQAGGMTV SVVGDRTPRR SAKIRDEVLR
ALQG
//
