ID U1GCA6_ENDPU Unreviewed; 1107 AA.
AC U1GCA6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=A-pheromone processing metallopeptidase Ste23 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EPUS_03670 {ECO:0000313|EMBL:ERF69678.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF69678.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; KE721401; ERF69678.1; -; Genomic_DNA.
DR RefSeq; XP_007804708.1; XM_007806517.1.
DR AlphaFoldDB; U1GCA6; -.
DR MEROPS; M16.020; -.
DR GeneID; 19238709; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_2_1; -.
DR OMA; WIFDEMK; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 33..194
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 220..400
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 406..694
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 698..879
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1107 AA; 126551 MW; 5004B6F372CF776A CRC64;
MANVRRITDD LERPSLDDRS YRVIELPNKL QALLVHDPET DKASASMNVN VGSYSDDDSM
PGMAHAVEHL LFMGTKKYPV ENEYSSYLSS HAGHSNAYTA PTQTNYFFEC AASSEAENAT
EVDNAASPPV NGVASSRSPF YGALDRFAQF FVEPLFLEST LDRELRAVDS ENKKNLQSDQ
WRLTQLSRTI SNPKHPFSKF STGNLETLRD LPEKRGVKIR EKFIEFYEKH YSANRMKLVV
LGKEPLDELE QWVDELFTGV KNKDLPENRW DGPEQPFTKA ELSTQIFAKP VMESRTLEMW
FPYPDEEDLY ETQPSRFLGH LLGHEGPGSI LAYIKEKGWA NGLSCGYYPL CPGTAFFDLD
IRLTPDGLEY YQDVMKVVFQ YISLMKEQPP LEWMFDEMKT IGDVNFRFKQ KSPASRFTSA
TSAVMQKPLP REWLLSGSTK LRKFDPDGIV RAMQYLRPDN FRMMIVSQDQ PVRLDKKEKW
YGTEYAVQDI PEDLLSELHK SWQSGARERP KELHLPHKNE FIPTRLDVEK KVTTEPATAP
KLIRHDEMMR VWYKKDDRFW VPKTNFLITI RSSMTYATPA NHVKTKLFCE LVKDSLSEYA
YDADISGLVY NTSGTVLGID VNIGGYSDKL PVLLEKVLRS MKELKVGPDR FKIIKERISR
GYKNWDYQKP YYQVGGYVRW LTHEQSWINH QYAAELPNIE ADDVQTFIPQ ILGHNHIEIL
AHGNLYKEDA LKMANLVETI LKPRPLPQSL WHLRRDMVLP SGSNYTYRRS LVDPGNVNHA
IEYSLLIGDR TDRKLKAKAQ LFAQMLHEPT FDQLRTKEQL GYVVFSGARL STASILYRVL
IQSEKDPDYL EGRIEAHLSR FRADLERMSD SEFEAHRRSV INRKQEKLKN LASETARLAD
NIGNEYFDFY KLDHDVVELK QLNKGDIQDF YNEFIDPHSK TRAKLSVHMV AQSTPNEEAK
LSPQQQSEAL LDALSKFLSS SGVSCDPETL KASLDKVDIP SGDQEGVLSA VKAYAESSLP
DEKIDSIAAQ LHEALPPLFM TLGIKSKSAA KEQEQEAEQD AAASGTVEKI PPVMVENVDT
WKAGLRVSEG PRPLVDLSEF EEMEPKL
//
