ID U1GFC5_9ACTN Unreviewed; 350 AA.
AC U1GFC5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Mur ligase middle domain-containing protein {ECO:0000313|EMBL:ERF55619.1};
DE Flags: Fragment;
GN ORFNames=H641_08014 {ECO:0000313|EMBL:ERF55619.1};
OS Cutibacterium granulosum DSM 20700.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium.
OX NCBI_TaxID=1160719 {ECO:0000313|EMBL:ERF55619.1, ECO:0000313|Proteomes:UP000016307};
RN [1] {ECO:0000313|EMBL:ERF55619.1, ECO:0000313|Proteomes:UP000016307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20700 {ECO:0000313|EMBL:ERF55619.1,
RC ECO:0000313|Proteomes:UP000016307};
RX PubMed=24053623; DOI=10.1186/1471-2164-14-640;
RA Mak T.N., Schmid M., Brzuszkiewicz E., Zeng G., Meyer R., Sfanos K.S.,
RA Brinkmann V., Meyer T.F., Bruggemann H.;
RT "Comparative genomics reveals distinct host-interacting traits of three
RT major human-associated propionibacteria.";
RL BMC Genomics 14:640-640(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERF55619.1}.
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DR EMBL; AOSS01000301; ERF55619.1; -; Genomic_DNA.
DR RefSeq; WP_021104605.1; NZ_AOSS01000301.1.
DR AlphaFoldDB; U1GFC5; -.
DR PATRIC; fig|1160719.4.peg.1508; -.
DR OrthoDB; 9803907at2; -.
DR Proteomes; UP000016307; Unassembled WGS sequence.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR013564; MurT_C.
DR PANTHER; PTHR23135:SF7; LIPID II ISOGLUTAMINYL SYNTHASE (GLUTAMINE-HYDROLYZING) SUBUNIT MURT; 1.
DR PANTHER; PTHR23135; MUR LIGASE FAMILY MEMBER; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR Pfam; PF08353; MurT_C; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ERF55619.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016307}.
FT DOMAIN 16..198
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
FT DOMAIN 236..338
FT /note="Lipid II isoglutaminyl synthase (glutamine-
FT hydrolyzing) subunit MurT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08353"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ERF55619.1"
SQ SEQUENCE 350 AA; 38326 MW; 6E527E1C3A072C3D CRC64;
AAVHASRGIE PDDIVTNADG ANLHAGIVSA LGQAPEARNA ILEVDERVVA DVVRQGHPCV
LVLLNFSRDQ LDRNHELTFL GREWREALEE AGEEGPTVVA NAADPLIVWA AQAAHRTVWV
DTKPRWTADS VLCPQCGSIL LHDDNGWRCE ECGLHQPKAD WWVDDQKAIR KDGHEYELEI
SVPGSFNLAN ATCALAAATE MGVDPYDALL GMREVSSPAG RYATTSINDV LVRLMLSKNP
AGWTESLPLA TSDPLILAID AVAADGKDVS WLWDVDYEQL VGRTVICTGP RALDLGVRLE
YAGVDHVVIE DLSDVFVCPL LQGRWDQPHP IDVLATYTPF QKLRRMGEHI
//
