ID U1GKD6_ENDPU Unreviewed; 345 AA.
AC U1GKD6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit {ECO:0000256|ARBA:ARBA00014912};
GN ORFNames=EPUS_06092 {ECO:0000313|EMBL:ERF72336.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF72336.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000256|ARBA:ARBA00008638}.
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DR EMBL; KE721110; ERF72336.1; -; Genomic_DNA.
DR RefSeq; XP_007802007.1; XM_007803816.1.
DR AlphaFoldDB; U1GKD6; -.
DR GeneID; 19241039; -.
DR eggNOG; KOG0794; Eukaryota.
DR HOGENOM; CLU_034754_2_0_1; -.
DR OMA; DDGPRYW; -.
DR OrthoDB; 102875at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20546; CYCLIN_SpCG1C_ScCTK2-like_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF7; CYCLIN-C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF028758; Cyclin, C/H/G types; 2.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 53..141
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 345 AA; 38536 MW; BDAE0885380DE923 CRC64;
MAANYWTSTQ RQFWHFTPSQ LVSIRSALAA QHAAVINQYP TSDPRHILIF LKDQLLRLSR
RQSRQQCLAT TLVYIHRYLL THPLQTINPY LLLTTAFYLA SKTEESPHHI RAVLGEARQF
WPEFLLGDVS RIGEMEFSLI SEMRSQLIIW HPYRTLIELK GPEKEGGLEL SNDEVGMAWS
IINDSYLTDL PLTCAPHTIA IMAIFLAVAF QPTNKVTAGV SGLPTFQIPS TPNPIINNTS
SASFQGLGGR QGMSAVINGV VNSSASIGPI VNAATDSKMK SNTKPVPSEK MQRIIRFLAE
SSIDLEQIIN ATQQIVSLYE VWESYSEKAV KESLARIIRG RGLDK
//
