ID   U1GL54_9ACTN            Unreviewed;       337 AA.
AC   U1GL54;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=AsnC family transcriptional regulator {ECO:0000313|EMBL:ERF57524.1};
GN   ORFNames=H641_02873 {ECO:0000313|EMBL:ERF57524.1};
OS   Cutibacterium granulosum DSM 20700.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Cutibacterium.
OX   NCBI_TaxID=1160719 {ECO:0000313|EMBL:ERF57524.1, ECO:0000313|Proteomes:UP000016307};
RN   [1] {ECO:0000313|EMBL:ERF57524.1, ECO:0000313|Proteomes:UP000016307}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20700 {ECO:0000313|EMBL:ERF57524.1,
RC   ECO:0000313|Proteomes:UP000016307};
RX   PubMed=24053623; DOI=10.1186/1471-2164-14-640;
RA   Mak T.N., Schmid M., Brzuszkiewicz E., Zeng G., Meyer R., Sfanos K.S.,
RA   Brinkmann V., Meyer T.F., Bruggemann H.;
RT   "Comparative genomics reveals distinct host-interacting traits of three
RT   major human-associated propionibacteria.";
RL   BMC Genomics 14:640-640(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERF57524.1}.
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DR   EMBL; AOSS01000091; ERF57524.1; -; Genomic_DNA.
DR   AlphaFoldDB; U1GL54; -.
DR   PATRIC; fig|1160719.4.peg.547; -.
DR   Proteomes; UP000016307; Unassembled WGS sequence.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.70.920; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30154:SF34; TRANSCRIPTIONAL REGULATOR AZLB; 1.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13404; HTH_AsnC-type; 2.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016307};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          8..45
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|Pfam:PF13404"
FT   DOMAIN          67..136
FT                   /note="Transcription regulator AsnC/Lrp ligand binding"
FT                   /evidence="ECO:0000259|Pfam:PF01037"
FT   DOMAIN          172..207
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|Pfam:PF13404"
SQ   SEQUENCE   337 AA;  37443 MW;  4CB3E21A685E24BF CRC64;
     MIDVYEQLDR HLAHLVQMDP RISWARAGRL LDISPTTAAH RWQRLADEGL VWVTTFPNLD
     RHLTAIVEVD CRTESLPSAI ATLCAHSMVV SVHETTGRRD LVLTIVAPDL PTLSDLVIDW
     IGSIPGVYNS RSAVVTAVVI GTESWRVNGL NLTEAERAQP HQTRELWALP NDELDQQLVT
     LLAKDGRASA SDLARQLDVP TSTLHRHLQK VLASRQILMR CDVAPGLGNW TMECTWMATV
     AFNHKVRVLE LLKQHPSLRS CLWVTGSDNL RVNFRVPHHG SIAKIEAETA KAIPGLAPTE
     TIVHLRSHKS MGWMLDRAGR CTGNLVCPPL LKESVEA
//