ID   U1I1A4_ENDPU            Unreviewed;      1028 AA.
AC   U1I1A4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EPUS_07941 {ECO:0000313|EMBL:ERF77035.1};
OS   Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX   NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF77035.1, ECO:0000313|Proteomes:UP000019373};
RN   [1] {ECO:0000313|Proteomes:UP000019373}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX   PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA   Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA   Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT   "Genome characteristics reveal the impact of lichenization on lichen-
RT   forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL   BMC Genomics 15:34-34(2014).
CC   -!- SIMILARITY: Belongs to the NEMF family.
CC       {ECO:0000256|ARBA:ARBA00008318}.
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DR   EMBL; KE720675; ERF77035.1; -; Genomic_DNA.
DR   RefSeq; XP_007785623.1; XM_007787433.1.
DR   AlphaFoldDB; U1I1A4; -.
DR   GeneID; 19242819; -.
DR   eggNOG; KOG2030; Eukaryota.
DR   HOGENOM; CLU_003612_1_1_1; -.
DR   OMA; MFLEFFA; -.
DR   OrthoDB; 129892at2759; -.
DR   Proteomes; UP000019373; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR   Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR   InterPro; IPR021846; NFACT-C.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR   Pfam; PF11923; NFACT-C; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   Pfam; PF05833; NFACT_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT   DOMAIN          553..666
FT                   /note="NFACT RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF05670"
FT   DOMAIN          975..1026
FT                   /note="NFACT protein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11923"
FT   REGION          692..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          902..988
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..787
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        808..830
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        831..869
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        920..957
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1028 AA;  113786 MW;  50D704B55F9E4AF0 CRC64;
     MKQRFSSLDV KVIVHEISKA VVNLRVSNIY DLSSRIFLFK LAKPGTREQL LVDSGFRCHL
     TSFARTTAAA PSAFVSKLRK YLKSRRITSV SQIGTDRVIE LVFSDGQYRV FLEFFAAGNI
     ILTDKEYNIL TLLRNVSEGN EEVDVKVGTR YPLAAKQNYA GIPPLTEERL TETLRNQVAR
     AETLAEVNAK KAKKKGGDDL RKALAMGFPE YPTHLLDHSF KETSVDASVK SAQALKDVGL
     LSKLMKAVEL CDRIFRSLGR EASSKGYIIA KAKNDGANEE TGGSERDATV PPREDLLYDD
     FHPFKPSQFE GKTGTFIIEI DGFNKTVDEF FSSIESQKLE SRLTEREENA KKKMEIARLE
     HEKRIGALQQ VQELHIRMAE AIEANAHRVE EAIAAVNGLI GQGMDWMDIA KLIENEQSRQ
     NVVAQMIKLP LKLYENTVTL LLDEASFEQE EDDGGYETDE LEESDDEEVT VKIKSSTEKR
     LAIDIDLALS PWANARQYYD QKKTAAQKEQ KTLQASSKAL KSTEQKISAD LKKGLKQEKD
     VLRPARKQFW FEKFWYFISS DGYLVLGGKD AQQNELLYRR YLKKGDIYVH ADLQGAASVV
     VKNAIDTPDA PIPPSTLSQA GSLSVCTSTA WDSKAVMAAW WVHADQVSKT APTGEYLSAG
     GFVIKGSKNF LPPAQLLLGF AVAFHISESS KKNHQKHRFQ HSDTTTPNTQ AQGMSDETGR
     LSIEEEAESS DHELHGESDQ EQAKDNEIEP KGGPQNSEDK EGSEQESANE SDPEHDSEAE
     REDRTQATNP LQTEAILENA QPLGEDSESS DEQSEEPAQA IEDIEDIEDP TETTTFNTAT
     STPTHSQPTT TQTPSTPSTP ASQKQTPAPR GKRTKAAKRA AAKYAHQDPA ERALALQLLG
     STKGASEKAQ AATMSKAARE AKLAADKERR KAQHDRAAAA EKRRMERLEK GSAAADGQDG
     EDEAEEDKEA AEQERRKLAN LDSLVGNPMP DDEILAALPI AAPWSALARY KYKVKLQPGA
     LKKGKAPD
//