ID U1KHQ3_9GAMM Unreviewed; 224 AA.
AC U1KHQ3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759};
GN ORFNames=PCIT_20974 {ECO:0000313|EMBL:ERG16544.1};
OS Pseudoalteromonas citrea DSM 8771.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1117314 {ECO:0000313|EMBL:ERG16544.1, ECO:0000313|Proteomes:UP000016487};
RN [1] {ECO:0000313|EMBL:ERG16544.1, ECO:0000313|Proteomes:UP000016487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8771 {ECO:0000313|Proteomes:UP000016487};
RX PubMed=22535931; DOI=10.1128/JB.00265-12;
RA Xie B.B., Shu Y.L., Qin Q.L., Rong J.C., Zhang X.Y., Chen X.L., Shi M.,
RA He H.L., Zhou B.C., Zhang Y.Z.;
RT "Genome sequences of type strains of seven species of the marine bacterium
RT Pseudoalteromonas.";
RL J. Bacteriol. 194:2746-2747(2012).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERG16544.1}.
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DR EMBL; AHBZ02000208; ERG16544.1; -; Genomic_DNA.
DR AlphaFoldDB; U1KHQ3; -.
DR STRING; 1117314.PCIT_20974; -.
DR eggNOG; COG3066; Bacteria.
DR OrthoDB; 5634909at2; -.
DR Proteomes; UP000016487; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00759};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759};
KW Reference proteome {ECO:0000313|Proteomes:UP000016487}.
FT DOMAIN 55..153
FT /note="DNA mismatch repair MutH/Type II restriction enzyme
FT Sau3AI"
FT /evidence="ECO:0000259|SMART:SM00927"
SQ SEQUENCE 224 AA; 24907 MW; 1C3D809AFA3D7859 CRC64;
MRKPNPPETI NELMQRVNDI AGVTLGELAN QYQFKTPEHL LREKGWPGQL LEYVLGASAG
SKPVPDFERL GIELKSLPIG YNGKPLETTY VTTVPLTGLT GATFDNSSVK KKLAHVLWLP
ILAERALQPV ERVIGSGFLW QPNAYQIAQL QRDWEEQIEL IALGEIEQIS GHLGEVMQIR
PKAANSKALT DVIGPNGQIT KTLPRGFYLK TQFTQQILAD HFQG
//
