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Database: UniProt
Entry: U1KM81_9GAMM
LinkDB: U1KM81_9GAMM
Original site: U1KM81_9GAMM 
ID   U1KM81_9GAMM            Unreviewed;       426 AA.
AC   U1KM81;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   31-JAN-2018, entry version 28.
DE   RecName: Full=Peptide methionine sulfoxide reductase MsrA {ECO:0000256|HAMAP-Rule:MF_01401};
DE            Short=Protein-methionine-S-oxide reductase {ECO:0000256|HAMAP-Rule:MF_01401};
DE            EC=1.8.4.11 {ECO:0000256|HAMAP-Rule:MF_01401};
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase {ECO:0000256|HAMAP-Rule:MF_01401};
DE            Short=Peptide Met(O) reductase {ECO:0000256|HAMAP-Rule:MF_01401};
GN   Name=msrA {ECO:0000256|HAMAP-Rule:MF_01401};
GN   ORFNames=PCIT_13411 {ECO:0000313|EMBL:ERG18104.1};
OS   Pseudoalteromonas citrea DSM 8771.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=1117314 {ECO:0000313|EMBL:ERG18104.1, ECO:0000313|Proteomes:UP000016487};
RN   [1] {ECO:0000313|EMBL:ERG18104.1, ECO:0000313|Proteomes:UP000016487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8771 {ECO:0000313|Proteomes:UP000016487};
RX   PubMed=22535931; DOI=10.1128/JB.00265-12;
RA   Xie B.B., Shu Y.L., Qin Q.L., Rong J.C., Zhang X.Y., Chen X.L.,
RA   Shi M., He H.L., Zhou B.C., Zhang Y.Z.;
RT   "Genome sequences of type strains of seven species of the marine
RT   bacterium Pseudoalteromonas.";
RL   J. Bacteriol. 194:2746-2747(2012).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine. {ECO:0000256|HAMAP-Rule:MF_01401}.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin. {ECO:0000256|HAMAP-
CC       Rule:MF_01401, ECO:0000256|SAAS:SAAS00970052}.
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC       {ECO:0000256|HAMAP-Rule:MF_01401, ECO:0000256|SAAS:SAAS00684647}.
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01401}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERG18104.1}.
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DR   EMBL; AHBZ02000140; ERG18104.1; -; Genomic_DNA.
DR   EnsemblBacteria; ERG18104; ERG18104; PCIT_13411.
DR   OrthoDB; POG091H064P; -.
DR   Proteomes; UP000016487; Unassembled WGS sequence.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; IEA:InterPro.
DR   GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006464; P:cellular protein modification process; IEA:UniProtKB-UniRule.
DR   GO; GO:0030091; P:protein repair; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 3.30.1060.10; -; 1.
DR   HAMAP; MF_01401; MsrA; 1.
DR   InterPro; IPR028427; Met_Sox_Rdtase.
DR   InterPro; IPR002569; Met_Sox_Rdtase_MsrA.
DR   InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf.
DR   InterPro; IPR002579; Met_Sox_Rdtase_MsrB.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR10173; PTHR10173; 2.
DR   Pfam; PF01625; PMSR; 1.
DR   Pfam; PF01641; SelR; 1.
DR   Pfam; PF13098; Thioredoxin_2; 1.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF55068; SSF55068; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
DR   PROSITE; PS51790; MSRB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016487};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01401,
KW   ECO:0000256|SAAS:SAAS00684651};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016487};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    426       Peptide methionine sulfoxide reductase
FT                                MsrA. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004615181.
FT   DOMAIN      301    425       MsrB. {ECO:0000259|PROSITE:PS51790}.
FT   ACT_SITE     47     47       {ECO:0000256|HAMAP-Rule:MF_01401}.
SQ   SEQUENCE   426 AA;  47808 MW;  2AD7F1F5186C4E3F CRC64;
     MSNSLKKPLL TAIFLVSSFS GYAGDMPMPQ PEQASMHVKT LVLGSGCFWG AEKRYEAMQG
     VIDAESGYAD GTGFKASYKE ITKRARQFDE HNYAEVVKVT YNANILTTQT LLQSYFESHD
     PTQKNRQGND IGTQYRSTIL FSEPEQQKMA FTLKATYQGL LSKNGYGKIQ TKIKPLGKFY
     PAEEYHQNYL VKNPNGYCPD HSTGVVFAPV ERETRDNKGI LSGKHIVVID SKNYCPYCEK
     LKKTVLNDYQ GDIPVHFRYA DELRGLKVKS ATWATPTILF MDDGKEVFGH QGFMDKPRFY
     KALGAFKLGD SEAYSIAFQK GTDRPFCKEY DLFKNTADGV FIDKLSGAAL FNTKDRFNSG
     TGWLSFKYPV KGSVTYHEDN SYGMKRTEIR SKSSGIHLGH VFANEGPGGS DRYCINATVL
     DFVANK
//
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