ID U1N9S7_9EURY Unreviewed; 396 AA.
AC U1N9S7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Probable porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00021723};
DE EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
GN ORFNames=J07HQW1_03619 {ECO:0000313|EMBL:ERG93555.1};
OS Haloquadratum walsbyi J07HQW1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloquadratum.
OX NCBI_TaxID=1238424 {ECO:0000313|EMBL:ERG93555.1, ECO:0000313|Proteomes:UP000030649};
RN [1] {ECO:0000313|EMBL:ERG93555.1, ECO:0000313|Proteomes:UP000030649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J07HQW1 {ECO:0000313|Proteomes:UP000030649};
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
CC -!- COFACTOR:
CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC Evidence={ECO:0000256|ARBA:ARBA00001916};
CC -!- SIMILARITY: Belongs to the HMBS family.
CC {ECO:0000256|ARBA:ARBA00005638}.
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DR EMBL; KE356560; ERG93555.1; -; Genomic_DNA.
DR AlphaFoldDB; U1N9S7; -.
DR STRING; 1238424.J07HQW1_03619; -.
DR HOGENOM; CLU_019704_1_0_2; -.
DR Proteomes; UP000030649; Unassembled WGS sequence.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR InterPro; IPR000860; HemC.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR NCBIfam; TIGR00212; hemC; 1.
DR PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR Pfam; PF01379; Porphobil_deam; 2.
DR Pfam; PF03900; Porphobil_deamC; 1.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..165
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 230..286
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 302..348
FT /note="Porphobilinogen deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03900"
FT REGION 166..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 42752 MW; EA0B6E89D7A0AB71 CRC64;
MTTRSRTRGT LTLATRGSDL ALRQATSVQE ALTDERYEVD LIEVETRGDQ IQDELIHQLG
KTGAFVRALD QEVLDPTAEA DAAVHSMKDM PTDSPDGLVV AGIPQRAPPG DLLITTDGQK
LSELPSGATV GTSSLRRQAQ LLDQRSDITV EPLRGNVDTR IEKLLAPSLQ TEHEQRIEAE
QDEMTDGESA RSDDKAEHAE EDEASEDLPE FEQSIEEWFN ELSEIERRAL ERSVETEYDA
IVLAEAGLQR SGLIHHIEYV KLDTATFVPA PGQGAIAITT QGKTDATTQI REAIDHPRTR
VETTVERTVL AELGGGCIAP IGVHATLQGE YVHVTARVLA GDGTETVSGS RNLPVDNHAA
AAAQFADKLA DRGADELITA ARVAADESNS TEPAGE
//
