ID U1NNS2_9EURY Unreviewed; 247 AA.
AC U1NNS2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000256|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000256|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000256|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000256|HAMAP-Rule:MF_00317};
GN ORFNames=J07HQX50_02810 {ECO:0000313|EMBL:ERG98763.1};
OS Haloquadratum sp. J07HQX50.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloquadratum.
OX NCBI_TaxID=1238426 {ECO:0000313|EMBL:ERG98763.1, ECO:0000313|Proteomes:UP000030642};
RN [1] {ECO:0000313|EMBL:ERG98763.1, ECO:0000313|Proteomes:UP000030642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J07HQX50 {ECO:0000313|Proteomes:UP000030642};
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- FUNCTION: Sliding clamp subunit. Responsible for tethering the
CC catalytic subunit of DNA polymerase to DNA during high-speed
CC replication. {ECO:0000256|RuleBase:RU003673}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|HAMAP-Rule:MF_00317, ECO:0000256|RuleBase:RU003671}.
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DR EMBL; KE356563; ERG98763.1; -; Genomic_DNA.
DR AlphaFoldDB; U1NNS2; -.
DR STRING; 1238426.J07HQX50_02810; -.
DR HOGENOM; CLU_043978_1_1_2; -.
DR Proteomes; UP000030642; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00317,
KW ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00317}; Reference proteome {ECO:0000313|Proteomes:UP000030642}.
FT DOMAIN 5..99
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 122..242
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 247 AA; 26970 MW; C514C16609448EBC CRC64;
MFKAIVGAST LEDALDSVSV LVDECKIRLN EDEFAIRAVD PANVGMVDLS LAADAFESYN
ADGGVIGVNL AKLEDFIGMA NGNQLIELEL DEQTRKLNIR MDGLSSTLAL IDPDSIRQEP
DIPDLDLPAE IVLEGAQLDR GIKAADMVSD HVRLRVNNQT EAYHIEAEGD TDDVDFELSA
DDLIRLTAGT ADSLFSLDYL KDMDKAIPKD AEVTIELGDE FPVKIHYQVA EGNGQITYML
APRIQSD
//
