ID U1PJB9_9EURY Unreviewed; 422 AA.
AC U1PJB9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Hydroxymethylglutaryl-CoA reductase {ECO:0000313|EMBL:ERH10541.1};
GN ORFNames=J07HX64_02316 {ECO:0000313|EMBL:ERH10541.1};
OS halophilic archaeon J07HX64.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales.
OX NCBI_TaxID=1085028 {ECO:0000313|EMBL:ERH10541.1};
RN [1] {ECO:0000313|EMBL:ERH10541.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; KE356579; ERH10541.1; -; Genomic_DNA.
DR STRING; 1085028.J07HX64_02316; -.
DR HOGENOM; CLU_649908_0_0_2; -.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 422 AA; 45272 MW; B9013139B0F845E4 CRC64;
MTDPADLAGR VHAGDLRLHE LDDHADAGTA AAARRAFLAT ETDADLDALG AFGFAAEQAA
ESNAENLVGG AQLPMGVAGP VTVDGGAATG EYYLPLATTE GALVASINRG LSTIERAGGA
TARVTDSGMT RAPVFRVDGV AEAGRVTEWV ADNTDRIRET AESTTSHGEL LAVDPYVVGD
SVFLRFVYDT KDAMGMNMAT IATRAAADLL ETETPAELVA LSGNLCSDKK PAAINAVEGR
GRTVTADVVL DRGLVEDRLD TTPEAMAXXX XXXXXXXXXX XXXXAATPTH SRRLSRPARS
RVNSPWWRRS AHVTSPVHTR SWVGEMTRFL RSGRRRDLCV LLAGDELQAQ ALKTRLEDHY
EERIDPESFY GALDALERNG FLETRAEGIH DVYALTDAGR ARLDEHVEWV LGAVDELDSG
ER
//
