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Database: UniProt
Entry: U1PNY6_9EURY
LinkDB: U1PNY6_9EURY
Original site: U1PNY6_9EURY 
ID   U1PNY6_9EURY            Unreviewed;       206 AA.
AC   U1PNY6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   08-MAY-2019, entry version 20.
DE   RecName: Full=Probable thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=J07HQW2_01894 {ECO:0000313|EMBL:ERG95437.1};
OS   Haloquadratum walsbyi J07HQW2.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
OC   Haloferacales; Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=1238425 {ECO:0000313|EMBL:ERG95437.1, ECO:0000313|Proteomes:UP000030710};
RN   [1] {ECO:0000313|EMBL:ERG95437.1, ECO:0000313|Proteomes:UP000030710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J07HQW2 {ECO:0000313|Proteomes:UP000030710};
RX   PubMed=23637883;
RA   Podell S., Ugalde J.A., Narasingarao P., Banfield J.F.,
RA   Heidelberg K.B., Allen E.E.;
RT   "Assembly-driven community genomics of a hypersaline microbial
RT   ecosystem.";
RL   PLoS ONE 8:E61692-E61692(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165}.
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DR   EMBL; KE356561; ERG95437.1; -; Genomic_DNA.
DR   STRING; 1238425.J07HQW2_01894; -.
DR   Proteomes; UP000030710; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030710};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:ERG95437.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165}.
FT   DOMAIN        7    186       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND       9     16       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   206 AA;  22762 MW;  AC7C50F02129D740 CRC64;
     MSTLITLEGL DGSGKSTVCE SLQSTLPEAT FTCEPTNSWY GDLVAESTHN NDADSLAELF
     LFTADHADHL SRVIRPSLAS GTTVISDRYA DSRYAYQAAT LEGSCIDAPL EYIQSVHEPF
     SRRPDATVYL DIDPETAVTR AGATNKFERA QYLERVATQY ERLIAAEPSR FHRVDATESI
     ADVRETVTMI VETVLDDKKS SELNDK
//
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