ID U1PWX8_9EURY Unreviewed; 414 AA.
AC U1PWX8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase {ECO:0000313|EMBL:ERG96941.1};
GN ORFNames=J07HQW2_03425 {ECO:0000313|EMBL:ERG96941.1};
OS Haloquadratum walsbyi J07HQW2.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloquadratum.
OX NCBI_TaxID=1238425 {ECO:0000313|EMBL:ERG96941.1, ECO:0000313|Proteomes:UP000030710};
RN [1] {ECO:0000313|EMBL:ERG96941.1, ECO:0000313|Proteomes:UP000030710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J07HQW2 {ECO:0000313|Proteomes:UP000030710};
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
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DR EMBL; KE356561; ERG96941.1; -; Genomic_DNA.
DR AlphaFoldDB; U1PWX8; -.
DR STRING; 1238425.J07HQW2_03425; -.
DR eggNOG; arCOG04611; Archaea.
DR HOGENOM; CLU_006051_3_0_2; -.
DR Proteomes; UP000030710; Unassembled WGS sequence.
DR GO; GO:0070204; F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd07037; TPP_PYR_MenD; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR004433; MenaQ_synth_MenD.
DR InterPro; IPR032264; MenD_middle.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR NCBIfam; TIGR00173; menD; 1.
DR PANTHER; PTHR42916; 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE; 1.
DR PANTHER; PTHR42916:SF1; PROTEIN PHYLLO, CHLOROPLASTIC; 1.
DR Pfam; PF16582; TPP_enzyme_M_2; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT DOMAIN 12..124
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 223..382
FT /note="Menaquinone biosynthesis protein MenD middle"
FT /evidence="ECO:0000259|Pfam:PF16582"
SQ SEQUENCE 414 AA; 44877 MW; FB2F4668CA4C0159 CRC64;
MSAPNRNTLW ARTFVSELAA GGVDAVCISP GSRSTPLTIA FDRHDDIETF SHLDERSAAY
FALGRARRTG SVTPVVCTSG TAAANYHPAV IEASQSRVPL LLLTADRPPE LHDSGANQTV
DQTKLYGDSV RWFHEIGEPE PTERKLRSLR TTAARSIITA TDTPAGPVHL NFSFRKPLEP
TPVPGDIPED FSEESITGRE DAFVESTVGN RMLDQNGIQT VADSLSAPRG LVVIGPLTTP
GVDPEAVAAF AHASGFPVLA DPLSGIRYGG VTRTTPVIGG YDSFLTDELW DQWPDPDVVL
RFGASPTSKP LRQYLEATTP TQYLVDPAGE WREATFSATD LIIADPTQLL WQLSRVLNNP
GSSTWRQRWL DADDAHANVL AETNSSTDQS TQPLTLTLTQ TQTQTQTQIQ MTAV
//
