ID   U1Q6B5_9ACTO            Unreviewed;       585 AA.
AC   U1Q6B5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HMPREF0043_01337 {ECO:0000313|EMBL:ERH17699.1};
OS   Actinobaculum sp. oral taxon 183 str. F0552.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinobaculum.
OX   NCBI_TaxID=1227261 {ECO:0000313|EMBL:ERH17699.1, ECO:0000313|Proteomes:UP000016495};
RN   [1] {ECO:0000313|EMBL:ERH17699.1, ECO:0000313|Proteomes:UP000016495}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0552 {ECO:0000313|EMBL:ERH17699.1,
RC   ECO:0000313|Proteomes:UP000016495};
RA   Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA   Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA   Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA   Pepin K.H., Bhonagiri V., Zhang X., Warren W., Mitreva M., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERH17699.1}.
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DR   EMBL; AWSB01000034; ERH17699.1; -; Genomic_DNA.
DR   AlphaFoldDB; U1Q6B5; -.
DR   STRING; 1227261.HMPREF0043_01337; -.
DR   PATRIC; fig|1227261.3.peg.1169; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_474772_0_0_11; -.
DR   Proteomes; UP000016495; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 2.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000016495}.
FT   DOMAIN          13..247
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   585 AA;  65049 MW;  A1262776D3A16A3C CRC64;
     MGNLTMNDGG PAGMKLSDTA ENALQSECPV LVLGGPGSGK TTLSLLKAKS YVSELAPEQA
     ILFLSFSRAA VRQVEIRCRD LLNAEEQRSI EVRTYHSFAL DILKTHGRLL TGTPPRILYP
     SEETLLKSCH SGLWEKEAKR LAAEEGRYVF GEFASAANKL LVGSKAVAKL IADKYPVVIL
     DEFQDTNDSQ WELVKTLSLL SRMVFLADPD QRIFDYDKHV SAERLHHLRN DLRPAEFDLG
     GNNHRSPNSG ILAYANAVLH NKAFPGSIGE IETITYYPNS FDKSVHFAVV STLSKLRKEG
     LERPSVAVLA RTNAMVAKTS DCLSQDHEFR SRPMKPIVHD VLWDTGLTTA AALVVASILE
     WTALPKVTAL AQTFELIAEY FDIKNASNSK GVKYAQEASK KYSNTAKSLK AGDKLRCEVT
     KHFEKVYDSE SLFIGRPADD WLKARVLLDT TTGKLNHVFG DVKFVRLFRA TDQIGGCLSD
     LWDRHGNYIN ASRLLRRPLS MQSLQSDYRE PVGCSLMTVH KAKGKEFDGV VIVDGHPKSA
     DAFFREKASP SERESARRLL RVAITRARRH VFLVRPYGAL PLADE
//