ID U2EPJ2_9FIRM Unreviewed; 638 AA.
AC U2EPJ2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=NADH-ubiquinone/plastoquinone family protein {ECO:0000313|EMBL:ERI94906.1};
GN ORFNames=HMPREF1982_00588 {ECO:0000313|EMBL:ERI94906.1};
OS Clostridiales bacterium oral taxon 876 str. F0540.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=1321778 {ECO:0000313|EMBL:ERI94906.1, ECO:0000313|Proteomes:UP000016490};
RN [1] {ECO:0000313|EMBL:ERI94906.1, ECO:0000313|Proteomes:UP000016490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0540 {ECO:0000313|EMBL:ERI94906.1,
RC ECO:0000313|Proteomes:UP000016490};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000256|ARBA:ARBA00008483}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERI94906.1}.
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DR EMBL; AWSZ01000015; ERI94906.1; -; Genomic_DNA.
DR AlphaFoldDB; U2EPJ2; -.
DR STRING; 1321778.HMPREF1982_00588; -.
DR PATRIC; fig|1321778.3.peg.584; -.
DR eggNOG; COG1009; Bacteria.
DR HOGENOM; CLU_013183_0_0_9; -.
DR Proteomes; UP000016490; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016490};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000313|EMBL:ERI94906.1}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..148
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 179..460
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 638 AA; 69563 MW; CA55B7B33222A5A0 CRC64;
MNTLIISLLV VPIVFALLFL LNNGKTYFKA LSYLLCAFGT IASVTLAIHG PVQLIIDGSA
FTTLEALITV LEILIIVFLF SVSMKHKRKG VFSLTFLQSI LFIYTAFFME KHHETVLNVD
SFSIVMLLLV NIIGTLIVVF ANGYITEYEH HRHMKSKQKL FYFVISIFIA AMNGLVMSDG
LAWIYFFWEI TTLASFMLIS YNGDAEAYQS GFRALFLNLI GGLCFSAGNI IFQSKYGITT
LSDIANYGSK SYVLLVPVFL LCVAGFAKSA QMPFQSWLLG AMVAPTPVSA LLHSSTMVKA
GVYLIIKLSP AYAGTKLGTA IALYGGITFL LCSAIAVTQR NAKRILAYST IANLGLIICS
AGMGTSLGIS AAIILIIFHA VSKALLFLCT GQIEHTIGSR DVEDMSGLIA KAPVLTLITA
FGLVSMILPP FGVLITKLIS IEAAAQNPFI VILLVLGSAL TTLYYIKWMG TILSYPAVKF
PNKETRDFNV YLPLWVLSIL VLLSSIFVSP VYNKLVSPEI KSLLPKAPEA LNISLANIST
QLGSFNNNIV FIVIAFVILI ALVVKGTLIG KPTRKNIYMC GENNAEDENL FRGPDGSYEK
AVVSNYYLTR IFDEKLMTRL GSLISVSIIL IVILGGLA
//
