ID U2IJW8_9STRE Unreviewed; 1223 AA.
AC U2IJW8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF1557_01839 {ECO:0000313|EMBL:ERJ74191.1};
OS Streptococcus sobrinus W1703.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1227275 {ECO:0000313|EMBL:ERJ74191.1, ECO:0000313|Proteomes:UP000016617};
RN [1] {ECO:0000313|EMBL:ERJ74191.1, ECO:0000313|Proteomes:UP000016617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1703 {ECO:0000313|EMBL:ERJ74191.1,
RC ECO:0000313|Proteomes:UP000016617};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Warren W., Mitreva M., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ74191.1}.
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DR EMBL; AWVA01000109; ERJ74191.1; -; Genomic_DNA.
DR RefSeq; WP_021674081.1; NZ_KI259719.1.
DR AlphaFoldDB; U2IJW8; -.
DR PATRIC; fig|1227275.3.peg.1650; -.
DR HOGENOM; CLU_001114_3_1_9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000016617; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 29..503
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 530..813
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 84..111
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1223 AA; 140597 MW; 50D0FDA38FD2E688 CRC64;
MSFPAFLSFA AIEELKQREP ERAKSQERLA RTPEQIQAIY SNGTNILVSA SAGSGKTFVM
VERIIDMLKR GVAINRLFIS TFTVKAAGEL KERLENRLEE EIAASQDLEL KQHLSSQMAD
LATADIGTMD AFSQKLVNTY GYSLGISPNF RIMQDESEQA SLKKEVYDDL FAAYMTGPDG
RIFRKLVRNF IGNSKDSRSF RSLVDSIYQF SQSTANPKQW LQEVLLRPYQ EDVKSQAQNF
LSTYLKSHRL AETLDQTEKF FKDHLEVARG EFQKKGKYQE NVENLLEVLA RVDLHGDLGQ
LYQDLQAIQT ISSGRNLTML AGRTADEDLK AFVKDYNEER KQILEPFLKL EQVLKPLELL
TDFQPDLLDL LELLRDFLAD YSQQYLEKKK GEAAFEFSDI AHLAIEILEA NPEIRQLYQA
KYQEVMVDEY QDNNHMQERL LDLLSNGHNR FMVGDVKQSI YRFRQADPKI FQAKFQTYDQ
PESFQVGKSQ GLLILLKENF RSHLEVLQTS NAVFSRLMDQ DIGELVYDQS HWLQAGNAQK
AEAIPANRTQ VFIYDDSQDQ KENQGQDLLE AGDIRLVAQE IIRLHKEEGV AFDQIALLVS
SRNRNDEILS TLKNYGLPVV SEDTGGHYLQ ALEVMVMLET LRTINNPLQD QSLVALLKSP
MFNFGEDLLT RISLQAKSGN FYDKLLLALS ETGDNPQLIT AQLHGKIQAF NQVLTAWRNF
AKTNSLHDLI WKIYEDKFYY DYVGALSNGQ QRQANLYALT VRANQFEKSG FKGLPRFINM
IDRVLNNEKD LADVEVALPK DAIQLMTIHQ SKGLEFPYVF ILNLHKSFNK EDEKNRAVLS
RDHGLGVRYV VNVADRFPQE KLTQLRLSFD TFPFLSNKQA LHRADLSEQM RKLYVAMTRA
ETRLYLVGRG SQAKLQGKYE NYRDQEHLAL AGREKWISFQ DWFLALKQNF PEADLAFDLN
FVSQEDLDQL TPLQPSLPLD VDDQSQNRQS DDIKQALDAL EAVEELNHRY QAAINLPTVR
TPSQIKKFYQ PVMEDQGLDI MEKRILEPKF DLPSFGKESR VTGAAIGSAT HELMQRLPIN
PNLSLADLQA TLKEVQAEPA VKQRINLTNL LEFFRHHSLG QEIMSQGDRL VREAPFAMLY
EDWESHEKMV IRGIVDGYIR YEDHIVLFDY KTDHYQSTSE LVQRYQDQMK LYAQALGKSF
DQTRIEKYLI LLGGKEVVVE KLD
//
