ID U2P2Y4_9BACT Unreviewed; 997 AA.
AC U2P2Y4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=HMPREF9135_1425 {ECO:0000313|EMBL:ERK38526.1};
OS Segatella baroniae F0067.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=1115809 {ECO:0000313|EMBL:ERK38526.1, ECO:0000313|Proteomes:UP000016648};
RN [1] {ECO:0000313|EMBL:ERK38526.1, ECO:0000313|Proteomes:UP000016648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0067 {ECO:0000313|EMBL:ERK38526.1,
RC ECO:0000313|Proteomes:UP000016648};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-binding oxidoreductase/transferase type
CC 4 family. {ECO:0000256|ARBA:ARBA00008000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK38526.1}.
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DR EMBL; AWEY01000038; ERK38526.1; -; Genomic_DNA.
DR RefSeq; WP_021590517.1; NZ_AWEY01000038.1.
DR AlphaFoldDB; U2P2Y4; -.
DR PATRIC; fig|1115809.3.peg.2197; -.
DR Proteomes; UP000016648; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13534; Fer4_17; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000016648}.
FT DOMAIN 39..267
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 587..616
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 997 AA; 111301 MW; A7CAA044BABA78BE CRC64;
MEPLRYDLFL TDIRRFVDDQ QIYTDELRTL AWGTDAGFYR LVPKIVIRSD GERQVSRILQ
ACDKHNIPYT FRAAGTSLSG QSISDSVLIV AGKHWERHEL LDDGQAIRLQ PGVVGGKVNQ
ILKPLGRVFP PDPASVSSAM VGGIVSNNAS GMNCGVHANS DRMLVSARLI LADGTIVDTG
SEESKEAFRK SHPRFIQQIE QLRDKVRGNK PLADRIRYKY SIKNVTGLNL RPLIAYNDPF
DIMAHSMVGS EGTLAFLAEV TMKTLKDYPF KASAMVYFKS MKESCEAIVK LKELVSGDQD
LAMSAENLMV KSAETLDYKS LSAVNDPVSL QYREDVDAGR IAGVMPGNYQ GLTAVLTETK
AVSHEALQKN VDTILSVLQS FDLYRPATFT EDPKVYNRYW AIRSGIFPSV GGTRPIGTSC
LIEDVAFHIE DLPEATVKLQ KLIANHGYDD ACIYGHAFAG NYHFILNQSF KSDMEVKRYE
KMMRDVTELV VKEFDGSLKA EHGTGRNMAP FVSYEWGAEA FEVMKELKAI FDPKGLLNPG
VIFNDNPDCF TQNLKDLPEL RFPYEKIPDG ERYLTLEQGK SSTQAMIQGV KDANKCIECG
FCEVNCVSCG LTLSSRMRIA IQREISHLEQ TGENPTLLRK LREQYRYQGD QTCASDGLCA
TSCPMKINTG NLTHLIRQIN MLDNRVGYKV GELGANHMAG IKCGLRGVLD LAHLGHSILG
DKLMTVLTEQ LHKAGMPLWT VAMPRPTRQP QRPKNQLKAG GERLKVVYFP SCINQTMGLS
KGAPVKKTVV DEMTSLMNKA GYEVVFPEGM HRMCCGQIWE SKGMMDIADR KSAELEAALW
KASEEGRYPV VCDQSPCLHR MRKVFTKMKL YEPVEFIMTY LKDRLVFHPT HKRIAIHVTC
STREMGLTDR MIELASLCSD HVLVPEGVGC CAFAGDKGFT HPELNRYALR KLRPQIENAD
IEVGYSNSRT CEIGLQSNAG IPYLNIAYLV NETTEAK
//
