ID U2PX61_9CLOT Unreviewed; 490 AA.
AC U2PX61;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=CINTURNW_4340 {ECO:0000313|EMBL:ERK28404.1};
OS Clostridium intestinale URNW.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1294142 {ECO:0000313|EMBL:ERK28404.1, ECO:0000313|Proteomes:UP000016721};
RN [1] {ECO:0000313|EMBL:ERK28404.1, ECO:0000313|Proteomes:UP000016721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=URNW {ECO:0000313|EMBL:ERK28404.1,
RC ECO:0000313|Proteomes:UP000016721};
RX PubMed=24136853;
RA Lal S., Ramachandran U., Zhang X., Sparling R., Levin D.B.;
RT "Draft Genome Sequence of the Hydrogen- and Ethanol-Producing Bacterium
RT Clostridium intestinale Strain URNW.";
RL Genome Announc. 1:e00871-13(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK28404.1}.
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DR EMBL; APJA01000035; ERK28404.1; -; Genomic_DNA.
DR RefSeq; WP_021804187.1; NZ_KI273145.1.
DR AlphaFoldDB; U2PX61; -.
DR STRING; 1294142.CINTURNW_4340; -.
DR PATRIC; fig|1294142.3.peg.4479; -.
DR eggNOG; COG0007; Bacteria.
DR eggNOG; COG1587; Bacteria.
DR HOGENOM; CLU_011276_6_3_9; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000016721; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ERK28404.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000016721};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERK28404.1}.
FT DOMAIN 3..212
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 263..480
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 490 AA; 54372 MW; 04ED6EF297C5A162 CRC64;
MSKVYLIGAG PGDEELITVK AVRKLKECTA VLYDRLVGNN VLNYINDDCE VYYCGKEPGS
HYKTQDEINQ TLVKLAKEGH IVGRVKGGDP YVFGRGGEEA LELVKENIDF EVIPGVTSAI
SVLNYGGIPI TQRAMSQSFH VVTGMSASSL KVNWEALAKE NGTLVFLMGL ENLEDIVERL
LANGKSKESK AAIIMRGTSS KQKKVVGTLE DIHSKSVEAG LKSPCIIVVG DVVELNESLD
WYGNKPLFGA NICVTRSRNQ ASKLRETLKD LGAEVTEINS IRFKDTSDNL NPYMDKLEDY
NHIVFTSVNG VNFFFDYLRN IKFDVRKLKA SFSVVGKATS KALTDRGIIP DLMAREFLGE
GLFKVLEPKL NKGEKVLIPC SLQARDYLSE EIRKLGLEVD KVSMYETIKG EVKNPRAFEE
VDMVLFTSPS TVNSMIEMVG IEALRDKKVV AIGPITLKTL IENKIDAVVC KEHSDDGLIE
EIKEIWRSLK
//
