ID U2Q162_9BACL Unreviewed; 227 AA.
AC U2Q162;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=adenosylhomocysteine nucleosidase {ECO:0000256|ARBA:ARBA00011974};
DE EC=3.2.2.9 {ECO:0000256|ARBA:ARBA00011974};
GN ORFNames=HMPREF1983_01338 {ECO:0000313|EMBL:ERK56465.1};
OS Gemella bergeri ATCC 700627.
OC Bacteria; Bacillota; Bacilli; Bacillales; Gemellaceae; Gemella.
OX NCBI_TaxID=1321820 {ECO:0000313|EMBL:ERK56465.1, ECO:0000313|Proteomes:UP000016637};
RN [1] {ECO:0000313|EMBL:ERK56465.1, ECO:0000313|Proteomes:UP000016637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700627 {ECO:0000313|EMBL:ERK56465.1,
RC ECO:0000313|Proteomes:UP000016637};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-
CC thioadenosine (hydrolase route): step 1/2.
CC {ECO:0000256|ARBA:ARBA00004945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK56465.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AWVP01000089; ERK56465.1; -; Genomic_DNA.
DR RefSeq; WP_021752878.1; NZ_KI271826.1.
DR AlphaFoldDB; U2Q162; -.
DR PATRIC; fig|1321820.3.peg.1296; -.
DR eggNOG; COG0775; Bacteria.
DR HOGENOM; CLU_031248_2_2_9; -.
DR UniPathway; UPA00904; UER00871.
DR Proteomes; UP000016637; Unassembled WGS sequence.
DR GO; GO:0008782; F:adenosylhomocysteine nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008930; F:methylthioadenosine nucleosidase activity; IEA:InterPro.
DR GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:UniProtKB-UniPathway.
DR GO; GO:0009164; P:nucleoside catabolic process; IEA:InterPro.
DR CDD; cd09008; MTAN; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR010049; MTA_SAH_Nsdase.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR NCBIfam; TIGR01704; MTA_SAH-Nsdase; 1.
DR PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR PANTHER; PTHR46832:SF1; 5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167}.
FT DOMAIN 2..225
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 227 AA; 25342 MW; D1545A64E7BA9939 CRC64;
MIALIGAMPE EVAIIRKKIK NLKENKIAHV NFYEGQYENK DIVLMLSLPG KVNAAIATTL
LLDNYDIDYV INIGTCGALQ GDMEIGDMIV ATEVRHFDVD ATEFGYEIGQ VPQMPAKYES
DKYLQQLAGE IVLPNHKIHF GLVGTSDSFI SNKKIKENIL KNFPTMQVVE MEAAAIAQTC
YQFNTKFIVC RSVSDKAEEG NRVTFDEFLK IAALNSSILT TELIKKL
//
