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Database: UniProt
Entry: U2QGW8_9FIRM
LinkDB: U2QGW8_9FIRM
Original site: U2QGW8_9FIRM 
ID   U2QGW8_9FIRM            Unreviewed;       727 AA.
AC   U2QGW8;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   13-NOV-2019, entry version 26.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=HMPREF1546_02822 {ECO:0000313|EMBL:ERK62145.1};
OS   Oscillibacter sp. KLE 1745.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Oscillospiraceae;
OC   Oscillibacter; unclassified Oscillibacter.
OX   NCBI_TaxID=1226323 {ECO:0000313|EMBL:ERK62145.1, ECO:0000313|Proteomes:UP000016601};
RN   [1] {ECO:0000313|EMBL:ERK62145.1, ECO:0000313|Proteomes:UP000016601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLE 1745 {ECO:0000313|EMBL:ERK62145.1,
RC   ECO:0000313|Proteomes:UP000016601};
RA   Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R.,
RA   Courtney L., Fronick C., O'Laughlin M., Godfrey J., Wilson R.M.,
RA   Miner T., Farmer C., Delehaunty K., Cordes M., Minx P., Tomlinson C.,
RA   Chen J., Wollam A., Pepin K.H., Bhonagiri V., Zhang X., Warren W.,
RA   Mitreva M., Mardis E.R., Wilson R.K.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERK62145.1}.
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DR   EMBL; AWVO01000172; ERK62145.1; -; Genomic_DNA.
DR   RefSeq; WP_021749371.1; NZ_KI271722.1.
DR   EnsemblBacteria; ERK62145; ERK62145; HMPREF1546_02822.
DR   PATRIC; fig|1226323.3.peg.2437; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; GCF_000469445-HMP:HMPREF1546_RS09340-MONOMER; -.
DR   Proteomes; UP000016601; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016601};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016601};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    283    300       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    346    370       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    425    449       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    455    475       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    514    532       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    552    569       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    576    599       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    619    639       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    651    671       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    683    702       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        2    163       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   727 AA;  79205 MW;  27C52686E2CD48E5 CRC64;
     MDMKIALAGN PNCGKTTLFN DLTGSNQYVG NWPGVTVEKK EGRLKGRKDI VIQDLPGIYS
     LSPYTLEEVV ARNYLVKEKP DAILNIVDGT NIERNLYLTT QLIELGLPVV VAVNMMDLVR
     RNGDQIDARK LSDALGCQVV EISALKGEGG VEAAELAAKM AQQKRAAELP HVFTGSVEHA
     IAHIEESIQG MVDDRYLRWY AVKVFERDEK VLADLNLSTD LRAHLEDHIV DCEKELDDDA
     ESIITNQRYA YINDLVTKAV KKKGEKHRLS TSDKIDQIVT NRILALPIFA VVMFAVYWIA
     MGPFGTFLTD WTNDVLGTAW LVEIPRAALE GWGVNEVVVG LICDGALAGV GAVLGFVPQM
     LVLFLMLAIL EDIGYMARIA FIMDRIFRKF GLSGKSFIPM LVGTGCGVPG VMASRTIENE
     RDRRMTVMTT CFIPCGAKMP IIGLIAGALF GGSGLVAASA YFIGVAAIVI SGIILKKTKM
     FAGDPAPFVM ELPAYHIPSV GNVLRATWER GWSFIKRAGT VILASSIILW FLQGFGWENG
     AFGLVEDMNN SVLAAIGSAV AFIFAPLGFG NWRATVAVVT GLIAKENVVA TFGVLYNFAG
     ELSENGDEIW ALVAQDYTAI SAYSFMIFNL LCAPCFAAMG AIKREMNNAK WTAFAIGYMC
     VFAYVVSLIV YQIGGLITGE VSFGIGTVVA VVLVVGIVYL LFRKNKYEDE RLTIRSVDAA
     GRRAALK
//
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