ID U2QJU2_9ACTN Unreviewed; 393 AA.
AC U2QJU2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=galactokinase {ECO:0000256|ARBA:ARBA00012315};
DE EC=2.7.1.6 {ECO:0000256|ARBA:ARBA00012315};
DE AltName: Full=Galactose kinase {ECO:0000256|ARBA:ARBA00029590};
GN Name=galK {ECO:0000313|EMBL:ERK63175.1};
GN ORFNames=HMPREF0682_1119 {ECO:0000313|EMBL:ERK63175.1};
OS Propionibacterium acidifaciens F0233.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propionibacterium.
OX NCBI_TaxID=553198 {ECO:0000313|EMBL:ERK63175.1, ECO:0000313|Proteomes:UP000017052};
RN [1] {ECO:0000313|EMBL:ERK63175.1, ECO:0000313|Proteomes:UP000017052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0233 {ECO:0000313|EMBL:ERK63175.1,
RC ECO:0000313|Proteomes:UP000017052};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC {ECO:0000256|ARBA:ARBA00006566}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK63175.1}.
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DR EMBL; ACVN02000015; ERK63175.1; -; Genomic_DNA.
DR RefSeq; WP_021796170.1; NZ_ACVN02000015.1.
DR AlphaFoldDB; U2QJU2; -.
DR OrthoDB; 250531at2; -.
DR Proteomes; UP000017052; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_N.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00131; gal_kin; 1.
DR PANTHER; PTHR10457:SF35; GALACTOKINASE; 1.
DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ERK63175.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERK63175.1}.
FT DOMAIN 19..68
FT /note="Galactokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10509"
FT DOMAIN 127..190
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 291..371
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 393 AA; 40777 MW; 25AF3E0751F28820 CRC64;
MTYEISSWPE AVGAARAAEL FTTAFGAEPA GVWASPGRVN LIGEHLDYNG GSSVPIALPH
ATYVALSPRE DGRVRITSDG AEPGLWTGAL ADVMPGGGQP TWVSYALGAA WVLSRAGHAL
TGVDAAIVSC VPTSAGLSSS AAIECAVGLA LVEVLGLPVG RRELVGVCQR AENEVVGAPT
GSMDQSASLL ADAGRALVLN TLDGSTELVP FDLSDRGLCL LVIDTRAKHA LVDGQYAARR
AACERVAARE GVDLLGRIAD PHALLERLDD PVELKRVRHV VTEIERVDAF VALLRAGDYD
RIGPLMDASH ASLRDDYEVS CPELDGAVDT ARAAGALGAR MTGGGFGGSA IALVPAGLVG
RVERAVEEAY AEHGWGPPRF IPAVAAEAGR RVR
//
