ID   U2RXU6_9ACTN            Unreviewed;       587 AA.
AC   U2RXU6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=HMPREF0682_0675 {ECO:0000313|EMBL:ERK55432.1};
OS   Propionibacterium acidifaciens F0233.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Propionibacterium.
OX   NCBI_TaxID=553198 {ECO:0000313|EMBL:ERK55432.1, ECO:0000313|Proteomes:UP000017052};
RN   [1] {ECO:0000313|EMBL:ERK55432.1, ECO:0000313|Proteomes:UP000017052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0233 {ECO:0000313|EMBL:ERK55432.1,
RC   ECO:0000313|Proteomes:UP000017052};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA   Methe B., Sutton G., Nelson K.E.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERK55432.1}.
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DR   EMBL; ACVN02000186; ERK55432.1; -; Genomic_DNA.
DR   AlphaFoldDB; U2RXU6; -.
DR   Proteomes; UP000017052; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   NCBIfam; TIGR00795; lctP; 1.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        72..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        102..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        142..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        191..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        282..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        343..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        395..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        436..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        458..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        564..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   587 AA;  61661 MW;  58EA5F7A71CCC64C CRC64;
     MSSQNGGRLA GEAFITHRPK NIERGVLVVL LEAFTPSTNP LGHQWASALV ALIPIACMLI
     TLGALRWKAH WAGLASWALA LVVAITAYHM PVTMAVSSSV EGFLYGLFPI GWILLAAIWM
     YQVTVISGRF DDLRRTFFLI SDDPRVLGIL IAFCFGGLLE ALAGFGAPVA IAAAMLIAVG
     FGKLRAAVTA LVANTVPVAF GAVGLPVLMA ARTGGLEVSQ VAPVTARICA ILCLVVPFLM
     LGIMDGRQGI KQCWPFGLFV GFIFGAVKWI VAGTGLYNLT EIFAAVISVG LAMVFLRFWK
     PRGGAEAAER IGIPMDPSLE TGPAGRTEEG GDKLTAGRIV MALVPYILVI VIFGIAAVPS
     VQALLKKADV KMAWPGLGEL LSTTGKASAH QSYTWPWLST PGFLLLIVAL LVGIIYRVSI
     RDLFGELLVN LKKMKFSLIT IGLVVALAYV MGDSGQTMAL GLFIAGAGAV YPFLAPILGW
     IGTYVTGSDT SANILFSGLQ SGIGEQIGDP ANLEAMRSLL VGSGAAGGVV GKMISPQSLT
     VAATAIGLAG GESTILRKVF KYSIVLIVFM CIIAGLMSTP VLGWLLP
//