ID   U2T7H3_LEIAQ            Unreviewed;       372 AA.
AC   U2T7H3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   ORFNames=N136_00209 {ECO:0000313|EMBL:ERK73418.1};
OS   Leifsonia aquatica ATCC 14665.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Leifsonia.
OX   NCBI_TaxID=1358026 {ECO:0000313|EMBL:ERK73418.1, ECO:0000313|Proteomes:UP000016605};
RN   [1] {ECO:0000313|EMBL:ERK73418.1, ECO:0000313|Proteomes:UP000016605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14665 {ECO:0000313|EMBL:ERK73418.1,
RC   ECO:0000313|Proteomes:UP000016605};
RA   Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA   O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA   Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERK73418.1}.
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DR   EMBL; AWVQ01000018; ERK73418.1; -; Genomic_DNA.
DR   RefSeq; WP_021758350.1; NZ_KI272038.1.
DR   AlphaFoldDB; U2T7H3; -.
DR   PATRIC; fig|1358026.3.peg.184; -.
DR   HOGENOM; CLU_039228_0_0_11; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000016605; Unassembled WGS sequence.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016605}.
FT   DOMAIN          20..365
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   372 AA;  40549 MW;  B53E4485E6093E85 CRC64;
     MSEQNAGYAL ADGTDIRALP KVSLHDHLDG GLRPSTVIEL GDAIGFELPT TDPVELARWF
     GEKSNSGSLV EYLKTFDLTT AVMQTREGLT RVAREFVQDL GADGVVYGEI RWAPEQHLTR
     GLSLDETVEA VQEGIEAGIQ DVRATGKRIR VGQLVSAMRH LDRGLEIAQL AVRHRDNGVV
     GFDIAGPEAG FPPANQRAAF DYLAENFFPA TVHAGEADGL DSIRSALLDG RALRLGHGVR
     IAEDISIERQ DDENTYVTLG TLSQWVKDRE IALETSPTSN LQTGAIAAWG TDILDHPFDL
     LYQLGFRVTV NTDNRLMSGT TLTRELSILA DAFAYDRTDL EIFQLNAAAG AFLPLEEREE
     LADIITAGFE GS
//