ID U2U0R7_9ACTN Unreviewed; 341 AA.
AC U2U0R7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=NADP oxidoreductase coenzyme F420-dependent {ECO:0000313|EMBL:ERL11783.1};
GN ORFNames=HMPREF1248_0122 {ECO:0000313|EMBL:ERL11783.1};
OS Coriobacteriaceae bacterium BV3Ac1.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae.
OX NCBI_TaxID=1111135 {ECO:0000313|EMBL:ERL11783.1, ECO:0000313|Proteomes:UP000016652};
RN [1] {ECO:0000313|EMBL:ERL11783.1, ECO:0000313|Proteomes:UP000016652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3AC1 {ECO:0000313|Proteomes:UP000016652};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL11783.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AWUP01000017; ERL11783.1; -; Genomic_DNA.
DR AlphaFoldDB; U2U0R7; -.
DR PATRIC; fig|1111135.3.peg.1298; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000016652; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000016652}.
FT DOMAIN 13..169
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 175..291
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 181
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 341 AA; 35830 MW; 4916FDA46077F04B CRC64;
MHDQHAQINA QSQVAFIGTG IMGAPIAKHI LDAGYDLTVF NRSKDKMATL VDAGAHEANS
IASAVENADV VITMLGYPTD VEDAYLATAG ILASSKKGAY LIDLTTSSPE LARDIHDAAE
VSGKHAFDCP VTGGQEGAEA GTLTLIIGAD EPTVAPVHPL LQTFSAKQYY FDAAGKGQLA
KLTNQVSLAS CMMGYADAMA LAEQADLDVQ QTLQMICDGM GGSVAMTRLA PKSLAGNYKP
GFLAEHLHKD LNLALASAQD LGITLPGAET AFTLYDLLCQ VGGSRMGTQA LTLLYADQET
GEAAGLDWSI LEAEQDEDEG CDCGHSHGHD HDCGCDHHHK D
//
