GenomeNet

Database: UniProt
Entry: U2WK02_9FIRM
LinkDB: U2WK02_9FIRM
Original site: U2WK02_9FIRM 
ID   U2WK02_9FIRM            Unreviewed;       548 AA.
AC   U2WK02;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE            EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE   AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN   ORFNames=HMPREF1985_00041 {ECO:0000313|EMBL:ERL25521.1};
OS   Mitsuokella sp. oral taxon 131 str. W9106.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC   Mitsuokella.
OX   NCBI_TaxID=1321781 {ECO:0000313|EMBL:ERL25521.1, ECO:0000313|Proteomes:UP000016614};
RN   [1] {ECO:0000313|EMBL:ERL25521.1, ECO:0000313|Proteomes:UP000016614}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W9106 {ECO:0000313|EMBL:ERL25521.1,
RC   ECO:0000313|Proteomes:UP000016614};
RA   Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA   O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA   Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000926};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERL25521.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AWVT01000001; ERL25521.1; -; Genomic_DNA.
DR   RefSeq; WP_021770894.1; NZ_KI273055.1.
DR   AlphaFoldDB; U2WK02; -.
DR   STRING; 1321781.HMPREF1985_00041; -.
DR   PATRIC; fig|1321781.3.peg.38; -.
DR   eggNOG; COG1227; Bacteria.
DR   eggNOG; COG2239; Bacteria.
DR   eggNOG; COG4109; Bacteria.
DR   HOGENOM; CLU_025243_1_0_9; -.
DR   OrthoDB; 9766150at2; -.
DR   Proteomes; UP000016614; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd02205; CBS_pair_SF; 1.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   InterPro; IPR010766; DRTGG.
DR   InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE-RELATED; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   Pfam; PF07085; DRTGG; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR   SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016614}.
FT   DOMAIN          74..131
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          254..310
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   548 AA;  60837 MW;  CE5BB1F0C523F1B3 CRC64;
     MKNTKPIYTI GHRNPDTDSI CSAIGYAHLK QALGENVVPA RAGKINAETK YALAYFKVEQ
     PLLLTDLYPR VKDVTLDCKI VVRQHDTLRR LGEVMREHDL KSVPVTDSKG ILVGIVTVSD
     LAKRYFQELG MQNLADMRVR YRDIIAATDS RVLVSGEEGD TIKGNVRIAA GSIQTIQNTV
     EENDIVIIGD RHDETLVDCL RQGISCLIVS GNGRVSADII EEAQKRHVFV LSTPYDTYTV
     ARLINQCVPI RRIMHADPVC FKPLDLLSDI KGTMEQTNYR NYPVLENGRL VGIVSSDQLM
     VPERERVILV DHNERGQAVE GIEEAKILEI IDHHRLGGIQ TSEPIYTHAE PVGCTATIIA
     NMHWHRDIDI PPSIAGLLLS AILSDTVLFR SPTCTPYDKK TAERLAEIAG VDVQAYGMDM
     LKAGSGIGDM TPQEIAKNDL KEFQIGDYRI IVSQISVMDT KEVMDLEDEL IAAMTNICEK
     EGFDMSLVMV TDILEEATYL LYAGSPKTLI GEAFKKDASG THVYLPGVMS RKKQIIPPLS
     EAVKRITK
//
DBGET integrated database retrieval system