ID U2WK02_9FIRM Unreviewed; 548 AA.
AC U2WK02;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN ORFNames=HMPREF1985_00041 {ECO:0000313|EMBL:ERL25521.1};
OS Mitsuokella sp. oral taxon 131 str. W9106.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Mitsuokella.
OX NCBI_TaxID=1321781 {ECO:0000313|EMBL:ERL25521.1, ECO:0000313|Proteomes:UP000016614};
RN [1] {ECO:0000313|EMBL:ERL25521.1, ECO:0000313|Proteomes:UP000016614}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W9106 {ECO:0000313|EMBL:ERL25521.1,
RC ECO:0000313|Proteomes:UP000016614};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474; EC=3.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000926};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL25521.1}.
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DR EMBL; AWVT01000001; ERL25521.1; -; Genomic_DNA.
DR RefSeq; WP_021770894.1; NZ_KI273055.1.
DR AlphaFoldDB; U2WK02; -.
DR STRING; 1321781.HMPREF1985_00041; -.
DR PATRIC; fig|1321781.3.peg.38; -.
DR eggNOG; COG1227; Bacteria.
DR eggNOG; COG2239; Bacteria.
DR eggNOG; COG4109; Bacteria.
DR HOGENOM; CLU_025243_1_0_9; -.
DR OrthoDB; 9766150at2; -.
DR Proteomes; UP000016614; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02205; CBS_pair_SF; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE-RELATED; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR Pfam; PF07085; DRTGG; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016614}.
FT DOMAIN 74..131
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 254..310
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 548 AA; 60837 MW; CE5BB1F0C523F1B3 CRC64;
MKNTKPIYTI GHRNPDTDSI CSAIGYAHLK QALGENVVPA RAGKINAETK YALAYFKVEQ
PLLLTDLYPR VKDVTLDCKI VVRQHDTLRR LGEVMREHDL KSVPVTDSKG ILVGIVTVSD
LAKRYFQELG MQNLADMRVR YRDIIAATDS RVLVSGEEGD TIKGNVRIAA GSIQTIQNTV
EENDIVIIGD RHDETLVDCL RQGISCLIVS GNGRVSADII EEAQKRHVFV LSTPYDTYTV
ARLINQCVPI RRIMHADPVC FKPLDLLSDI KGTMEQTNYR NYPVLENGRL VGIVSSDQLM
VPERERVILV DHNERGQAVE GIEEAKILEI IDHHRLGGIQ TSEPIYTHAE PVGCTATIIA
NMHWHRDIDI PPSIAGLLLS AILSDTVLFR SPTCTPYDKK TAERLAEIAG VDVQAYGMDM
LKAGSGIGDM TPQEIAKNDL KEFQIGDYRI IVSQISVMDT KEVMDLEDEL IAAMTNICEK
EGFDMSLVMV TDILEEATYL LYAGSPKTLI GEAFKKDASG THVYLPGVMS RKKQIIPPLS
EAVKRITK
//