ID   U2YKX1_9SPHN            Unreviewed;       372 AA.
AC   U2YKX1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE            EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN   Name=wecB {ECO:0000313|EMBL:GAD48977.1};
GN   ORFNames=NT2_04_03900 {ECO:0000313|EMBL:GAD48977.1};
OS   Caenibius tardaugens NBRC 16725.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Caenibius.
OX   NCBI_TaxID=1219035 {ECO:0000313|EMBL:GAD48977.1, ECO:0000313|Proteomes:UP000016568};
RN   [1] {ECO:0000313|EMBL:GAD48977.1, ECO:0000313|Proteomes:UP000016568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16725 {ECO:0000313|EMBL:GAD48977.1,
RC   ECO:0000313|Proteomes:UP000016568};
RA   Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Novosphingobium tardaugens NBRC 16725.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC         Evidence={ECO:0000256|ARBA:ARBA00036080};
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD48977.1}.
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DR   EMBL; BASZ01000004; GAD48977.1; -; Genomic_DNA.
DR   RefSeq; WP_021689884.1; NZ_CP034179.1.
DR   AlphaFoldDB; U2YKX1; -.
DR   KEGG; ntd:EGO55_08340; -.
DR   eggNOG; COG0381; Bacteria.
DR   OrthoDB; 9803238at2; -.
DR   Proteomes; UP000016568; Unassembled WGS sequence.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR   CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   NCBIfam; TIGR00236; wecB; 1.
DR   PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR   PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016568}.
FT   DOMAIN          24..369
FT                   /note="UDP-N-acetylglucosamine 2-epimerase"
FT                   /evidence="ECO:0000259|Pfam:PF02350"
SQ   SEQUENCE   372 AA;  40197 MW;  28BC23297DBCF403 CRC64;
     MALKILTVFG TRPEAIKMFP LVHALRGDSR FVSRVCVTGQ HRGMLDQVLA IAGVAPDHDL
     NVMQPDQSLD ALTARLLTGI GQVLDAERPD WVVVQGDTAT AMCGALAAYY RKIPVAHVEA
     GLRSGNIHHP WPEEINRKII GTMARLHCAP TETAADALKR ENTDPAAIHV TGNTVIDALH
     WVTAQIREKP ELAAGLTELE ARFAGKRIIG VTSHRRENFG DGMQGIARAI RQIAARDDVA
     LIFPVHLNPH VQSVMEAELA GLDNVALIAP LDYPHFARLI DIATLMLTDS GGVQEEAPAL
     GKPVLVMRET TERPEGVEAG TARLVGTDSD RIVAETFRLL DDSDAYAAMA RAHNPFGDGH
     SAHRIVELLA TG
//