ID U2YQB9_9SPHN Unreviewed; 686 AA.
AC U2YQB9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Putative fatty acid oxidation complex alpha subunit {ECO:0000313|EMBL:GAD51160.1};
GN ORFNames=NT2_24_00050 {ECO:0000313|EMBL:GAD51160.1};
OS Caenibius tardaugens NBRC 16725.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Caenibius.
OX NCBI_TaxID=1219035 {ECO:0000313|EMBL:GAD51160.1, ECO:0000313|Proteomes:UP000016568};
RN [1] {ECO:0000313|EMBL:GAD51160.1, ECO:0000313|Proteomes:UP000016568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16725 {ECO:0000313|EMBL:GAD51160.1,
RC ECO:0000313|Proteomes:UP000016568};
RA Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Novosphingobium tardaugens NBRC 16725.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD51160.1}.
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DR EMBL; BASZ01000024; GAD51160.1; -; Genomic_DNA.
DR RefSeq; WP_021691978.1; NZ_CP034179.1.
DR AlphaFoldDB; U2YQB9; -.
DR KEGG; ntd:EGO55_04535; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000016568; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000016568}.
FT DOMAIN 297..474
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 477..561
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 598..681
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 686 AA; 73507 MW; CED9C0E866B4B4A4 CRC64;
MRINDCTTLE RDGGIAIITV DSPPVNSLSV AVRKGVAEAM MQAAGDSAVA AVVLICGGRT
FFAGADITEF GKPVIEPDLR ALQQIVEDMP KPVIAAIHGA ALGGGLELAL VAHGRIAVPS
AQCGLPEVRL GLMPGAGGTQ RLPRVVGAAR ALEMMTSGDP ISAAEAARLG LLDRIADEGA
LRDEAVAFAR AVAADGAPLA RIRDRPLVVE QGLFDAFREA NGRKFRGLMA PESIIRSVEQ
GIALPFPQAL ENERALFCAL LEGAQSAALR HVFFAQRQAA KVDAISADTP IRPIIRVGVV
GAGTMGGGIA MNFANVGLPV TIVETRQEAL DRGLRIIRRN YENSAKKGKL TAEQVAQRMA
CLTGSLALED LADCDLVIEA VFEQLDVKQE LFRRLDLIAK PSAIVATNTS YLDIDRIAEV
TGRPENVLGL HFFSPANVMR LLEIVKAAKT DLSVLATAVA LAKKIGKIGV VVGNCYGFVG
NRMLAARHAQ AEAVVTEGAL PWDVDRVIRD FGFAMGPFEM RDLVGLDVGW NRATSSGATV
REMLNEMGRH GQKTGGGYYD YDEKRQPTPS PIAEQAVLDF SERHGGQRRI VSDEEIRDRV
LLAMVNEGAK ILDEGIAQRS SDIDLVWING YGWPAYRGGP MYWADTVGLP VIRDKLKALH
ATHGEVFRLS PLIERLVAQG KDFASL
//
