ID U2ZAD6_PSEA4 Unreviewed; 1002 AA.
AC U2ZAD6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=PA6_045_00050 {ECO:0000313|EMBL:GAD64686.1};
OS Pseudomonas alcaligenes (strain ATCC 14909 / DSM 50342 / JCM 20561 / NBRC
OS 14159 / NCIMB 9945 / NCTC 10367 / 1577).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1215092 {ECO:0000313|EMBL:GAD64686.1, ECO:0000313|Proteomes:UP000016560};
RN [1] {ECO:0000313|EMBL:GAD64686.1, ECO:0000313|Proteomes:UP000016560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14909 / DSM 50342 / JCM 20561 / NBRC 14159 / NCIMB 9945 /
RC NCTC 10367 / 1577 {ECO:0000313|Proteomes:UP000016560};
RA Yoshida I., Hosoyama A., Tsuchikane K., Noguchi M., Hirakata S., Ando Y.,
RA Ohji S., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Pseudomonas alcaligenes NBRC 14159.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD64686.1}.
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DR EMBL; BATI01000045; GAD64686.1; -; Genomic_DNA.
DR AlphaFoldDB; U2ZAD6; -.
DR STRING; 43263.A0T30_15620; -.
DR eggNOG; COG0744; Bacteria.
DR Proteomes; UP000016560; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016560}.
FT DOMAIN 126..316
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
SQ SEQUENCE 1002 AA; 111601 MW; B371FE5F59535CC9 CRC64;
MFWPLLILAL VALGIAAYRE FTNARLQARE FSRYAATLSY RVEPGPSSAI RFPSDGPFDK
RLGYTHLPLL LERLRERHFL ITAQARQSPP LLAYAMHGFF PPFAEKQQAG LAIADCRGEP
LYLFRYPQQL YPQFTDIPPL VVDSLLFIEN RHLLAADQPL ANPAVDWPRF AKAALSQVGK
SFAIQEQSAG GSTLATQLEK YRHSPDGLTL SAMEKLRQMV SASVRAYQQG PQTLAARQRI
VRDYLNSVPL SAAPGHGEVH GLADGLRVWF GADFARVNAL LDPARTPLAN RAERGLALRQ
VLALMIAQRR PSYYLAQGRK ELEALTDSHI RVLAGGGVID WTLRDAALAQ RLKFRDLQQY
PAIQPVQANK GISVARSRLS SLLNLPLYDL DRLDLAATST LNDALQQQVS AYLRQLADPE
FAGQVGLFGE RLLSPEKTAE VRYSFTLFER SPDGARVRVQ TDNTDQPFDL NEGSKLELGS
TAKLRVLTTY LEVIAELHGR YAGQSPEALR RVEVAAQDHL SRWVLDQLIA KPELGLRDTL
EAALERQYSA NPYETFFTGG GAHSFSNFKR EDNARIPTLR VALQESINLP FIRLLRDLVR
YSTYHGANNS AALLQDDQHP LRAGYLKRFA DREGTTFLLR FWRKYQGQSA QQRLDTFLEG
LRPTAVRLAA VHRYLMPEVD QATFATFIRA HANDKAEKLT DKKLQALYLD YGPGAWSLPD
QGYIARVHPL ELWLLGYLIE NPQATFKDAV AASAEERQEV YGWLFKTRHK SARDSRIRTL
LEVEAFLDIH QRWKRLGYPF EHLVPSLATA IGSSGDRPAA LAELMGIIQN DGIRQPSVRI
DRLHFAAATP YETQLQQDSQ RGQRVLPSEV AAALRGALSQ VVEAGTARRL HGSFQLADGT
PLVLGGKTGT GDNRIESTTR GGHVLSSRAM NRTATFVFYL GPRHFGTLTA FVPGQAAEKF
RFTSALPVQV LKGMAPLLTP YLEPAAQTGC GQPPGAVQVR RL
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