ID   U2ZYN7_VIBPR            Unreviewed;       622 AA.
AC   U2ZYN7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Peptidase M48 domain-containing protein {ECO:0000259|Pfam:PF01435};
GN   ORFNames=VPR01S_03_01210 {ECO:0000313|EMBL:GAD66212.1};
OS   Vibrio proteolyticus NBRC 13287.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=1219065 {ECO:0000313|EMBL:GAD66212.1, ECO:0000313|Proteomes:UP000016570};
RN   [1] {ECO:0000313|EMBL:GAD66212.1, ECO:0000313|Proteomes:UP000016570}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 13287 {ECO:0000313|EMBL:GAD66212.1,
RC   ECO:0000313|Proteomes:UP000016570};
RA   Isaki S., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y., Tsuchikane K.,
RA   Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A., Fujita N.;
RT   "Whole genome shotgun sequence of Vibrio proteolyticus NBRC 13287.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD66212.1}.
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DR   EMBL; BATJ01000003; GAD66212.1; -; Genomic_DNA.
DR   RefSeq; WP_021704202.1; NZ_BATJ01000003.1.
DR   AlphaFoldDB; U2ZYN7; -.
DR   STRING; 1219065.VPR01S_03_01210; -.
DR   eggNOG; COG0501; Bacteria.
DR   Proteomes; UP000016570; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07340; M48B_Htpx_like; 1.
DR   Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR   InterPro; IPR001915; Peptidase_M48.
DR   PANTHER; PTHR43221; PROTEASE HTPX; 1.
DR   PANTHER; PTHR43221:SF2; PROTEASE HTPX HOMOLOG; 1.
DR   Pfam; PF01435; Peptidase_M48; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016570};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        16..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          105..335
FT                   /note="Peptidase M48"
FT                   /evidence="ECO:0000259|Pfam:PF01435"
FT   REGION          357..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  68454 MW;  ED5FBC3840CD600F CRC64;
     MNFAQHQDRA KTRTGLLVVL FFLALLSITV VASLLIVIAT SWDNGHTSLN LNEILAFGAI
     SFVCVAAIVG ISSAYRLHQL SKHGGQAVAE QLGGKLISTN TSDFKQRRLL NVVEEMALAS
     GMPVPPVYLL TEEHGINAFA AGMSIDDAII GVTQGALDTF NRDELQGVMA HEFSHILNGD
     MRLNTRLIGT LFGITCMGLL GQALMRGAMQ SQRRASQFRS SNDKDKGSGA GLILVIALVL
     TVFGWLGTQF GSMIKAAISR QREFLADASA VQFTRNDRGI ANALKKIATH SQQSQLQAES
     TKEVSHMMFG QAQLSGLSAM LYATHPPLHE RILRIQPDWD GNFTEHAQVS TTNDEVAGLS
     GFSAPHSHDA PLTSEQKSQV GQRVMQQLPD ALLELAREPY SARFIPLLLI FDGSDEQREL
     IDRMLPEGSH QEYMPWLDFE LKAHLRLPLL ELAVPALKSM SPEQVSNFCL GLTEMAKLDN
     HYALNEWCVI NLMEKLVSPP KHPAPQRKTL QTVKESVIWV LRELSWLSQT SAQASATAYQ
     RALQHLTLPM TELDAANSNW SLTRSALEQL VQLRPADKQR FLEACKMVIE SDGKVSVSEG
     ELFRVIACFL EVAVPPLTID AE
//