ID U3A494_9SPHN Unreviewed; 349 AA.
AC U3A494;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:GAD49578.1};
GN ORFNames=NT2_06_00170 {ECO:0000313|EMBL:GAD49578.1};
OS Caenibius tardaugens NBRC 16725.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Caenibius.
OX NCBI_TaxID=1219035 {ECO:0000313|EMBL:GAD49578.1, ECO:0000313|Proteomes:UP000016568};
RN [1] {ECO:0000313|EMBL:GAD49578.1, ECO:0000313|Proteomes:UP000016568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16725 {ECO:0000313|EMBL:GAD49578.1,
RC ECO:0000313|Proteomes:UP000016568};
RA Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Novosphingobium tardaugens NBRC 16725.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD49578.1}.
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DR EMBL; BASZ01000006; GAD49578.1; -; Genomic_DNA.
DR RefSeq; WP_021690483.1; NZ_CP034179.1.
DR AlphaFoldDB; U3A494; -.
DR KEGG; ntd:EGO55_19315; -.
DR eggNOG; COG1420; Bacteria.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000016568; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016568};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 112..334
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 349 AA; 37153 MW; 1218893B8822E687 CRC64;
MPAPPVTELT NRARDIFRLV VEEYLQSGNP VGSKALAGAG AGQVNLSPAS IRSVLAELET
LGLLAAPHTS AGRMPTEIGL RLFVDGMMQV AEPTAEERAA IERRLSRPGP IEKALEATSA
LLSDLSAAAG VVMVPRREPR LSQMNLVQLA PGKALAILVG EDGSIENRLL TLPSGLPLSV
LEQATNYMTS RLGGRTLSEA ARVIGEEIAS GHSELDGASR DLVERGLAVW SEDATMRPVL
IVRGQANLLD ETALGDLERV RQLLDDLENK QSIAELLESA RDAEATRIFI GSENRLFALS
GSSVIASPYR DREGRVVGVL GVIGPTRLNY ARVVPMVDFT AQSLGKLIG
//
