ID   U3AVD3_CALJA            Unreviewed;       260 AA.
AC   U3AVD3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=BTB/POZ domain-containing protein KCTD21 {ECO:0000313|EMBL:JAB04178.1};
DE   SubName: Full=Potassium channel tetramerization domain containing 21 {ECO:0000313|Ensembl:ENSCJAP00000058506.1};
GN   Name=KCTD21 {ECO:0000313|EMBL:JAB04178.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000058506.1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB04178.1};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000058506.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:JAB04178.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Bladder {ECO:0000313|EMBL:JAB04178.1}, Cerebellum
RC   {ECO:0000313|EMBL:JAB48239.1}, Cerebral cortex
RC   {ECO:0000313|EMBL:JAB26760.1}, and Hippocampus
RC   {ECO:0000313|EMBL:JAB12949.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT   sequences.";
RL   Gigascience 3:14-14(2014).
RN   [3] {ECO:0000313|Ensembl:ENSCJAP00000058506.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; GAMT01007683; JAB04178.1; -; mRNA.
DR   EMBL; GAMS01010187; JAB12949.1; -; mRNA.
DR   EMBL; GAMR01007172; JAB26760.1; -; mRNA.
DR   EMBL; GAMP01004516; JAB48239.1; -; mRNA.
DR   STRING; 9483.ENSCJAP00000058506; -.
DR   Ensembl; ENSCJAT00000081981.2; ENSCJAP00000058506.1; ENSCJAG00000043935.2.
DR   GeneTree; ENSGT00940000160906; -.
DR   OMA; ANIFCTS; -.
DR   OrthoDB; 2912088at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008225; Chromosome 11.
DR   Bgee; ENSCJAG00000043935; Expressed in ovary and 6 other cell types or tissues.
DR   GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   CDD; cd18395; BTB_POZ_KCTD21; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045763; KCTD11/21_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14499:SF57; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21; 1.
DR   PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF19329; KCTD11_21_C; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          3..72
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
SQ   SEQUENCE   260 AA;  29640 MW;  E94BAD45B2106070 CRC64;
     MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL
     NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV
     QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD
     PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS
     SHPHALDFKN NKIIRLIRYR
//