ID U3AVX9_9VIBR Unreviewed; 420 AA.
AC U3AVX9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=VAZ01S_098_00190 {ECO:0000313|EMBL:GAD77910.1};
OS Vibrio azureus NBRC 104587.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1219077 {ECO:0000313|EMBL:GAD77910.1, ECO:0000313|Proteomes:UP000016567};
RN [1] {ECO:0000313|EMBL:GAD77910.1, ECO:0000313|Proteomes:UP000016567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 104587 {ECO:0000313|EMBL:GAD77910.1,
RC ECO:0000313|Proteomes:UP000016567};
RA Isaki S., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y., Tsuchikane K.,
RA Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A., Fujita N.;
RT "Whole genome shotgun sequence of Vibrio azureus NBRC 104587.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD77910.1}.
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DR EMBL; BATL01000098; GAD77910.1; -; Genomic_DNA.
DR RefSeq; WP_021711645.1; NZ_BATL01000098.1.
DR AlphaFoldDB; U3AVX9; -.
DR STRING; 1219077.VAZ01S_098_00190; -.
DR eggNOG; COG1257; Bacteria.
DR OrthoDB; 9794902at2; -.
DR Proteomes; UP000016567; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016567}.
SQ SEQUENCE 420 AA; 45241 MW; 6B6574D2493115AE CRC64;
MPKLHLNSAM HRTDLTEIET SEKIQSALEP KFHKPNVKLC LSPSLTEKNI ERRWKVLESY
TDKTLLLDDF TRSHFEQYSH NIEHFIGTVN LPVGVAGPLR VNGLYANTDY LVPLATTEAA
LVASYNRGAN LITAAGGAST LVISEGVSRT PVFAFQSLAE AAQFVSWVVT QYDIFRKEAE
STTTHGKLKD INVHIEGNHV YLVFEYVTGD ASGQNMVTIA THNVFHYILN HSPVTPIEAF
LDGNLSGDKK ANSHTLRSVR GKKVSAEITI PTELVQKYLH TTPESMVKFG KMTMVGGLLS
GSIGINAHYA NALTALYIAC GQDAACVAES AVGITRMDVN AEGNLYASVT LPNIMVGTVG
GGTGLPTQKA CLDILGLHGN GKAKALAEVA AALCLAGELS IVGAFCADHF SRAHHKLARK
//
