ID U3C187_CALJA Unreviewed; 334 AA.
AC U3C187; F7FZD3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=G-protein coupled receptor 12 {ECO:0000313|EMBL:JAB11929.1, ECO:0000313|Ensembl:ENSCJAP00000035909.2};
GN Name=GPR12 {ECO:0000313|EMBL:JAB11929.1,
GN ECO:0000313|Ensembl:ENSCJAP00000035909.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB11929.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000035909.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB11929.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB44573.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB33102.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB11929.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000035909.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; GAMS01011207; JAB11929.1; -; mRNA.
DR EMBL; GAMR01000830; JAB33102.1; -; mRNA.
DR EMBL; GAMP01008182; JAB44573.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000035909; -.
DR Ensembl; ENSCJAT00000037921.3; ENSCJAP00000035909.2; ENSCJAG00000019338.4.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01060000248564; -.
DR HOGENOM; CLU_065071_0_0_1; -.
DR OMA; ELIVNPW; -.
DR OrthoDB; 5397365at2759; -.
DR TreeFam; TF330052; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000019338; Expressed in cerebellum and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR CDD; cd15961; 7tmA_GPR12; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000599; GPR12.
DR InterPro; IPR000723; GPR_3/6/12_orphan.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF8; G-PROTEIN COUPLED RECEPTOR 12; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00650; GPR12ORPHANR.
DR PRINTS; PR00644; GPRORPHANR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:JAB11929.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..301
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 334 AA; 36784 MW; E2F99033722A9EBF CRC64;
MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPVVEPEP ELVVNPWDIV LCTSGTLISC
ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLIIN FVFAYLLQSE ATKLVTIGLI
VASFSASVCS LLAITVDRYL SLYYALTYHS ERTVTFTYVM LIMLWGTSIC LGLLPVMGWN
CLRDESTCSV VRPLTKNNAA ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT
SHYVTTRKGV STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI
YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV
//
