ID U3DTN3_CALJA Unreviewed; 1314 AA.
AC U3DTN3; F6WYH9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=TRIM5alpha {ECO:0000256|ARBA:ARBA00032496};
GN Name=RNF123 {ECO:0000313|EMBL:JAB13130.1,
GN ECO:0000313|Ensembl:ENSCJAP00000007766.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB13130.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000007766.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB13130.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB06775.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB51700.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB13130.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000007766.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; GAMT01005086; JAB06775.1; -; mRNA.
DR EMBL; GAMS01010006; JAB13130.1; -; mRNA.
DR EMBL; GAMP01001055; JAB51700.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000007766; -.
DR Ensembl; ENSCJAT00000008210.5; ENSCJAP00000007766.3; ENSCJAG00000004025.5.
DR eggNOG; KOG2242; Eukaryota.
DR eggNOG; KOG4692; Eukaryota.
DR GeneTree; ENSGT00940000155781; -.
DR HOGENOM; CLU_006687_2_0_1; -.
DR OrthoDB; 3145419at2759; -.
DR TreeFam; TF313546; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008225; Chromosome 15.
DR Bgee; ENSCJAG00000004140; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0051604; P:protein maturation; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd16541; RING-HC_RNF123; 1.
DR CDD; cd12882; SPRY_RNF123; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR045129; RNF123/RSPRY1-like.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035773; SPRY_RNF123.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 74..254
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1254..1292
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 1314 AA; 148676 MW; 5E33B1E2E4E4C279 CRC64;
MASKGAGMSF SRKSYRLTSD AEKSRVTGIV QEKLLNDYLN RIFSSSDHAP PAATSRKPLN
FQNLPEHLDL LLQVDDEEEE SQGQVEGRLG PSTVVLDHTG GFEGLLLVDD DLLGVIGHSN
FGTIRSTTCV YKGKWVYEVL ISSQGLMQIG WCTISCRFNQ EEGVGDTHNS YAYDGNRVRK
WNVTTTNYGK AWAAGDIVSC LIDLDDGTLS FCLNGVSLGT AFENLSRGLG MAYFPAISLS
FKESVAFNFG SRPLRYPVAG YRPLQDPPSA DLVRAQRLLG CFRAVLSVEL DPMEGQLLDK
ESSEWRLRGQ PTVLLTLAHI FHHFAPLLRK VYLVEAVLMS FLLGIVEKGT RAQAQSVVHQ
VLDLLWLFME DYEVQDCLKQ LMMSLLRLYR FSPIVPDLGL QIHYLRLTIA ILRHEKSRKF
LLSNVLFDVL RSVVFFYIKS PLRVEEAGLQ ELIPTTWWPH RSNKEGKESS EMKEETAEER
LRRRAYERGC QRLKKRIEVV EELQVQILKL LLDNKDGNGG EASRYIFLTK FRKFLQENAS
GRGNMPMLCP PEYMVCFLHR LISALRYYWD EYKASNPHAS YSEEAYIPPQ VFYNGKVDYF
DMQRLGGLLS HLRKTLKDDL ASKANIVIDP LELQATTMDD LDEDEEPAPA MAQRPMQTLA
VGGSLPLPRP SWLSSPTLGR ANRFLSTAAV SLMTPRRPLS TSEKVKVRTL SVEQRTREDI
EGSHWNEGLL LGRPPEEPEQ PLTENSLLEV LDGVVMMYNL SVHQQLGKMV GVSDDVNEYA
VALRDTEDKL RRCPEWRKDI FAELTKSQKV FSEKLDHLSR RLAWVHATVY SQEKMLDIYW
LLRVCLRTIE HGDRTGSLFA FMPEFYLSVA INSYSALKNY FGSVHSMEEL PGYEETLTRL
AAILAKHFAD TRIVGTDIRD SLMQALASYV CYPHSLRAVE RIPEEQRIAM VRNLLAPYEQ
RPWAQTNWIL VRLWRGCGFG YRYTRLPHLL KTKLEDANLP SLQKPCPSTL LQRHMADLLR
QGPDVAPSFL NSVLNQLNWA FSEFIGMIQE IQQAAERLER NFVDSRQLKV CATCFDLSVS
LLRVLEMTIT LVPEIFLDWT RPTSEMLLRR LAQLLNQVLN RVTAERNLFD RVVTLRLPGL
ESVDHYPILV AVTGILVQLL VRGPASERER ATSVLLADPC FQLRSICYLL GQPDPPAPGT
TLPAPDRKHF SLQSYADYIS ADELAQVEQM LAHLTSASAQ AAAASLPTSE EDLCPICYAH
PISAVFQPCG HKSCKACINQ HLMNNKDCFF CKATIVSVED WEKAASTSTT SSAA
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