ID U3EHN4_CALJA Unreviewed; 490 AA.
AC U3EHN4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
GN Name=SMYD1 {ECO:0000313|EMBL:JAB41789.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB41789.1};
RN [1] {ECO:0000313|EMBL:JAB41789.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAB41789.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR EMBL; GAMQ01000063; JAB41788.1; -; mRNA.
DR EMBL; GAMQ01000062; JAB41789.1; -; mRNA.
DR EMBL; GAMQ01000061; JAB41790.1; -; mRNA.
DR AlphaFoldDB; U3EHN4; -.
DR STRING; 9483.ENSCJAP00000064161; -.
DR InParanoid; U3EHN4; -.
DR OrthoDB; 166337at2759; -.
DR Bgee; ENSCJAG00000019356; Expressed in heart and 2 other cell types or tissues.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd10526; SET_SMYD1; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 1.25.40.970; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044418; SMYD1_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF184; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 7..253
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 52..90
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 490 AA; 56523 MW; FEC8EAA8784CED05 CRC64;
MTIGRMENVE VFTAEGKGRG LKATKEFWAA DVIFAERAYS AVVFDSLVNF VCHTCFKRQE
KLHRCGQCKF AHYCDRTCQK DAWLNHKNEC SAIRRYGKVP NENIRLAARI MWRVEREGTG
LTEGCLVSVD DLQNHVEHFG KEEQKELRVD VDTFLQYWPP QSQQFSMQYI SHIFGVINCN
GFTLSDQRGL QAVGVGIFPN LGLVNHDCWP NCTVIFNNGN HEAVKSMFHT QMRIELRALG
KISEGEELTV SYIDFLNVSE ERKKQLKKQY YFDCTCEHCQ KKLKDDLFLG VKDNPKASQE
VVKEMIQFSK DTLEKIDKAR SEGLYHEVVK LCRECLQKQE PVFADTNIYM LRLLSIVSEV
LSYLQAFEEA SDYARRMVDG YMKLYHPNNA QLGMAVMRAG LTNWHAGNIE VGHGMICKAY
AILLVTHGPS HPITKDLEAM RVQTEMELRM FRQNEFMYYK MREAALNNQP MQVMAEPSNE
PAPALFHKKQ
//
