ID U3EUI3_CALJA Unreviewed; 254 AA.
AC U3EUI3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Post-GPI attachment to proteins factor 2 {ECO:0000256|ARBA:ARBA00016871};
GN Name=PGAP2 {ECO:0000313|EMBL:JAB48202.1,
GN ECO:0000313|Ensembl:ENSCJAP00000094114.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB48202.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000094114.1, ECO:0000313|Proteomes:UP000008225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB48202.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB05719.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB48202.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB24530.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB13061.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB39625.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000094114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC maturation. Required for stable expression of GPI-anchored proteins at
CC the cell surface. {ECO:0000256|ARBA:ARBA00024944}.
CC -!- SUBUNIT: Interacts with PGAP2IP. {ECO:0000256|ARBA:ARBA00011213}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}.
CC -!- SIMILARITY: Belongs to the PGAP2 family.
CC {ECO:0000256|ARBA:ARBA00007414}.
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DR EMBL; GAMT01006142; JAB05719.1; -; mRNA.
DR EMBL; GAMS01010075; JAB13061.1; -; mRNA.
DR EMBL; GAMR01009402; JAB24530.1; -; mRNA.
DR EMBL; GAMQ01002226; JAB39625.1; -; mRNA.
DR EMBL; GAMP01004553; JAB48202.1; -; mRNA.
DR RefSeq; XP_002754893.1; XM_002754847.4.
DR RefSeq; XP_009005775.1; XM_009007527.2.
DR Ensembl; ENSCJAT00000135914.1; ENSCJAP00000094114.1; ENSCJAG00000015470.5.
DR GeneID; 100415147; -.
DR KEGG; cjc:100415147; -.
DR CTD; 27315; -.
DR GeneTree; ENSGT00510000047299; -.
DR OrthoDB; 3668913at2759; -.
DR Proteomes; UP000008225; Chromosome 11.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR InterPro; IPR039545; PGAP2.
DR PANTHER; PTHR12892; FGF RECEPTOR ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR12892:SF11; POST-GPI ATTACHMENT TO PROTEINS FACTOR 2; 1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 254 AA; 29304 MW; 64F02A1135FA8959 CRC64;
MYQVPLPLDR DGTLVRLRFT LVALVTVCCP LVAFLFCILW SLLFHFKETT ATHCGVPNYL
PSVSSAIGGE VPQRYVWRFC IGLHSAPRFL VAFAYWNHYL SCASPCSCYR PLCRINFGLN
VVENLALLVL TYVSSSEDFT IHENAFIVFI ASSLGHMLLT CILWRLTKKH TVSQEDRKSY
SWKQRLFIIN FVSFFSALAV YLRHNMYCEA GVYTIFAILE YTVVLTNMAF HMTAWWDFGN
KELLITSQPE EKRF
//
