ID U3FGM8_CALJA Unreviewed; 920 AA.
AC U3FGM8; F7I1S5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Neutral sphingomyelinase activation associated factor {ECO:0000313|Ensembl:ENSCJAP00000073038.1};
DE SubName: Full=Protein FAN isoform 1 {ECO:0000313|EMBL:JAB40761.1};
GN Name=NSMAF {ECO:0000313|EMBL:JAB40761.1,
GN ECO:0000313|Ensembl:ENSCJAP00000073038.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB40761.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000073038.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB40761.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB02636.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB40761.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000073038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMT01009225; JAB02636.1; -; mRNA.
DR EMBL; GAMQ01001090; JAB40761.1; -; mRNA.
DR Ensembl; ENSCJAT00000108998.2; ENSCJAP00000073038.1; ENSCJAG00000008834.6.
DR GeneTree; ENSGT00940000155059; -.
DR HOGENOM; CLU_000218_5_2_1; -.
DR Proteomes; UP000008225; Chromosome 16.
DR Bgee; ENSCJAG00000008834; Expressed in heart and 6 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 189..286
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 290..575
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 713..743
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 762..803
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 804..845
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 885..920
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 920 AA; 104766 MW; 80623F44F76FC427 CRC64;
MAFIRKKQQE QQLQLYSKER FSLLLLNLEE YYFEQHRANH IWHKDSHHER KIRGSLKICS
KSVIFEPDAI SQPIIKIPLR DCITIGKHGE NGANRHFTKA KSGGISLIFS QVYFIKEHNV
VAPYKIERGK MEYVFELDVP GKVEDVVETL LQLHRASCLD KLGDQTAMIT AILQSRLART
SFDKNRFQNI CERLHMECKA EMVTPLVTNP GHVCITDTNL YFQPLNGYPK PVVQITLQDV
RRIYKRRHGL MPLGLEVFCT EDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHVAEHTAES
YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII HDYSSSELDL SNPGTFRDLS
KPVGALNKER LERLLTRYQE MHEPKFMYGS HYSSPGYVLF YLVRIAPEYM LCLQNGRFDN
ADRMFNSIAE TWKNCLDGAT DFKELIPEFY GDDVSFLVNS LKLDLGKRQG GQMVDDVELP
PWASSPEDFL QKSKDALESS YVSEHLHEWI DLIFGYKQKG SDAVGAHNVF HPLTYEGGVD
LTSIQDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSWSQTSSYN ASMADSPVSP
GEESFEDLTE ESKTLAWDSI AKLQLHEQYK IHKEAVTGIT VSRNGSSVFT TSQDSTLKMF
SKESKMLQRS ISFSNMALSS CLLLPGDATV ISSSWDNNVY FYSIAFGRRQ DTLMGHDDAV
SKICWHDNRL YSASWDSTVK VWSGVPAEMP GTKRHHFDLL AELEHDVSVD TISLNAASTL
LVSGTKEGTV NIWDLTTATL MHQIPCHSGI VCDTAFSPDS RHVLSTGADG CLNVIDVQTG
MLISSMTSDE PQRCFVWDGN SVLSGSQSGE LLIWDLLGAK ISERIQGHTG AVTCIWMNEQ
CSSIITGGED RQIIFWKLQY
//
