ID U3FNX3_CALJA Unreviewed; 324 AA.
AC U3FNX3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000256|ARBA:ARBA00040184};
DE AltName: Full=Solute carrier family 35 member A4 {ECO:0000256|ARBA:ARBA00041939};
GN Name=SLC35A4 {ECO:0000313|EMBL:JAB47111.1,
GN ECO:0000313|Ensembl:ENSCJAP00000065906.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB47111.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000065906.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB47111.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB05734.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB47111.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB24189.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB12175.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB34725.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000065906.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000256|ARBA:ARBA00036682};
CC -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC {ECO:0000256|ARBA:ARBA00038552}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMT01006127; JAB05734.1; -; mRNA.
DR EMBL; GAMS01010961; JAB12175.1; -; mRNA.
DR EMBL; GAMR01009743; JAB24189.1; -; mRNA.
DR EMBL; GAMQ01007126; JAB34725.1; -; mRNA.
DR EMBL; GAMP01005644; JAB47111.1; -; mRNA.
DR RefSeq; XP_008984573.2; XM_008986325.2.
DR STRING; 9483.ENSCJAP00000065906; -.
DR Ensembl; ENSCJAT00000067673.2; ENSCJAP00000065906.1; ENSCJAG00000038978.2.
DR GeneTree; ENSGT00950000182827; -.
DR OMA; SSCVVMI; -.
DR OrthoDB; 4641608at2759; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000038978; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF96; UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000313|EMBL:JAB47111.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022597, ECO:0000313|EMBL:JAB47111.1}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 324 AA; 34826 MW; 1AADEB2051680429 CRC64;
MSVEDGGMQG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVNGRVPFRP SSAVLLTELT
KLLLCAFSFL VGWQAWPEGA PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN
LKIGSTALLY CFCLRHRLSV RQGLALLLLM TAGACYAAGG LQVPGNTFPS PPPAAAASPM
PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGSS
PGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL
QLTATFFLAT LLIGLAMHLY YGSR
//
