ID U3FTY8_CALJA Unreviewed; 738 AA.
AC U3FTY8; F7I4G6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Semaphorin 4D {ECO:0000313|Ensembl:ENSCJAP00000014617.3};
DE SubName: Full=Semaphorin-4D isoform 2 {ECO:0000313|EMBL:JAB51501.1};
GN Name=SEMA4D {ECO:0000313|EMBL:JAB51501.1,
GN ECO:0000313|Ensembl:ENSCJAP00000014617.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB51501.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000014617.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB51501.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51501.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB27832.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB21324.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000014617.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; GAMS01001812; JAB21324.1; -; mRNA.
DR EMBL; GAMR01006100; JAB27832.1; -; mRNA.
DR EMBL; GAMP01001254; JAB51501.1; -; mRNA.
DR Ensembl; ENSCJAT00000015415.5; ENSCJAP00000014617.3; ENSCJAG00000007883.5.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159594; -.
DR OMA; PCLKFRS; -.
DR TreeFam; TF316102; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000007883; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11259; Sema_4D; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..500
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 594..693
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 551..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 82110 MW; 674B07B070FC5ECD CRC64;
MKMRTPIRGL LMAFAVVFGT AMAFAPMPRI TWEHREVRLM QFHEPDIYNY SALLLSEDQD
TLYIGAREVI FAVNALNVSE KQHEVHWKVS EDKKAKCAEK GKSKQTECLN YIRVLQPLSA
TSLYVCGTNA FQPACDYLSL TSFKFLGRNE DGKGRCPFDP AHSYTSVIVD GELYSGTSYN
FLGSEPIISR NSSSSPLRTE YAIPWLNEPN FVFADVIRKS PDSPNGGDDR VYFFFTEVSV
EYEFVFRLQI PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSSLIF NVLRDVFVLR
SPGLKGPVFY ALFSPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSATVEQ SHTKWVRYNG
PVPKPRPGAC IDSEVRAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PRLIKKDVNY
TQIVVDRTQA LDGTVYDVMF VSTDRGALHK AISLEHSVHI IEETQLFQDF EPVQTLLLSS
KKGRRFVYAG SNSGVVQAPL AFCGKHSTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR
ALIQEMSGDA SVCPASSPKP LPSPGSSSLS CLGHAGDGRP SSPWTPWPAS HAGPDSSSSV
SLLPPFLSDQ AQHVHVLGTF HLFCQATGPA DIRFVWEKNG RALETCVPVQ THALPNGRAH
VLSWLQDAIR ESAEYRCSVL SSAGNKTSKV QVAVMRPEAT HQEKWTRELS AWRAVAGEHD
RMMQSWRKAW ESCSKDTL
//
