ID U3GV24_9CORY Unreviewed; 790 AA.
AC U3GV24;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=PASTA domain-containing protein {ECO:0000259|PROSITE:PS51178};
GN ORFNames=CARG_00590 {ECO:0000313|EMBL:AGU14318.1};
OS Corynebacterium argentoratense DSM 44202.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1348662 {ECO:0000313|EMBL:AGU14318.1, ECO:0000313|Proteomes:UP000016943};
RN [1] {ECO:0000313|EMBL:AGU14318.1, ECO:0000313|Proteomes:UP000016943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44202 {ECO:0000313|EMBL:AGU14318.1};
RX PubMed=24092787;
RA Bomholt C., Glaub A., Gravermann K., Albersmeier A., Brinkrolf K.,
RA Ruckert C., Tauch A.;
RT "Whole-Genome Sequence of the Clinical Strain Corynebacterium
RT argentoratense DSM 44202, Isolated from a Human Throat Specimen.";
RL Genome Announc. 1:e00793-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP006365; AGU14318.1; -; Genomic_DNA.
DR RefSeq; WP_020975439.1; NC_022198.1.
DR AlphaFoldDB; U3GV24; -.
DR STRING; 1348662.CARG_00590; -.
DR GeneID; 78249001; -.
DR KEGG; caz:CARG_00590; -.
DR PATRIC; fig|1348662.3.peg.111; -.
DR eggNOG; COG0744; Bacteria.
DR HOGENOM; CLU_006354_2_6_11; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000016943; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06577; PASTA_pknB; 1.
DR Gene3D; 3.30.10.20; -; 1.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS51178; PASTA; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016943}.
FT DOMAIN 688..750
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 747..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 83114 MW; 9F0C0F812BE70216 CRC64;
MSSLKSLGQL TAAIAAAGLA TALTLTPLAV LGGAGVSRAE ETMDSNLTDL TEGSAPGVTT
INDAAGESIA WIYKQRRFDV PSNQIAKPMK QAIVSVEDRR FYEHEGVDWK GALRAMGRNI
IKGAVSEGAS TIDQQYVKNY LLLVDAEDEA EQQLAVEQSI PRKLREMRMA SDLDRRHDKD
EILARYLNIV PFGNGAYGVE AASRTYFGIH ASELSVAQAA MLAGIVQSSS LLDPYTNPEG
VAERRATVLD TMVESGAITI EQAQAIKQEP LGVLEQPQGL PNGCIAAGDR GFFCDYVLDY
LSKKGLDFDE VATGAYTIDT TLDPATQAAA RQAVTSQVSP TTPGVAEVMN VVEPGEKSRK
VVAMASSRDY GLDLDAGQTV LPQPFTRVGA GAGSVFKVFT AAVALEKGMG VDTMVDVPPR
FEARGMGDGG AKNCPPDTYC VENSGLYKPQ MTLKQALAQS PNTTFVKLIE QLGVSNVVDM
SVSLGLRDYV EPGSFDGESS IAEYVKSHNL GSYTLGPTAV NPLELANVSA TIASGGMWCE
PNPINKVLDR HGQAVDLDVP DCERAVPENV AAALANALSE DVVDGTAADA AKAAGWRAPT
AAKTGTTESH FSAAFMGFNS RLAAVPYVYN DGVTPTPLCT SPLRQCPDGD LYGGMEPART
WFAAARGIPG AADGVLPAMD PKFGRGLGVS DLPSVRGLSE GDARKRLEKA GYKVSITFVP
GDGMPRGRVV GIRTGEAVMQ GDTLTLELSD GSSRPSAPPS PAQPEVQVGN DVADDLGAVI
DDLLRSLGAN
//
