ID U3GXK1_9CORY Unreviewed; 361 AA.
AC U3GXK1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=CARG_03020 {ECO:0000313|EMBL:AGU14756.1};
OS Corynebacterium argentoratense DSM 44202.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1348662 {ECO:0000313|EMBL:AGU14756.1, ECO:0000313|Proteomes:UP000016943};
RN [1] {ECO:0000313|EMBL:AGU14756.1, ECO:0000313|Proteomes:UP000016943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44202 {ECO:0000313|EMBL:AGU14756.1};
RX PubMed=24092787;
RA Bomholt C., Glaub A., Gravermann K., Albersmeier A., Brinkrolf K.,
RA Ruckert C., Tauch A.;
RT "Whole-Genome Sequence of the Clinical Strain Corynebacterium
RT argentoratense DSM 44202, Isolated from a Human Throat Specimen.";
RL Genome Announc. 1:e00793-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP006365; AGU14756.1; -; Genomic_DNA.
DR RefSeq; WP_020975907.1; NC_022198.1.
DR AlphaFoldDB; U3GXK1; -.
DR STRING; 1348662.CARG_03020; -.
DR GeneID; 78249431; -.
DR KEGG; caz:CARG_03020; -.
DR PATRIC; fig|1348662.3.peg.595; -.
DR eggNOG; COG1024; Bacteria.
DR HOGENOM; CLU_009834_22_1_11; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000016943; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000016943}.
FT DOMAIN 29..358
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 361 AA; 39775 MW; 34CF4CA6CD6A00E1 CRC64;
MAHDTDVSTN DASTVPDNLV YAHVVGTTGR LELNRPRALN SLNLEMVEII LDYLEQWRDD
PSVTHILITS TSERAFCAGG DVRAIREQGM QGQYAEGDRF FNTEYKMNEM LAVYPKPIVS
LIHGVVMGGG LGVSAHGSHR VVTEKTFAAM PEMLIGFIPD VGMSWRMQKM VGGKGYASVA
LANFLATTGM YLKPADMLWS GLATHYIDSS KMDEFVEAVI DESKGVDAAI EAHTTTVAES
SELARWEKQI EQCFAASSWS EIRANLEACA DAEFVDLVRE HTKLANPTSL VATIEVIAAT
VECSHIGQSL GHELTMGNQL RREPNFAEGV RAVLIDKDRN PSFVPNDIAE VDEQFYRDLL
R
//
