ID U3I2L6_ANAPP Unreviewed; 562 AA.
AC U3I2L6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Receptor like tyrosine kinase {ECO:0000313|Ensembl:ENSAPLP00000001486.2};
GN Name=RYK {ECO:0000313|Ensembl:ENSAPLP00000001486.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000001486.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000001486.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000001486.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3I2L6; -.
DR STRING; 8840.ENSAPLP00000001486; -.
DR Ensembl; ENSAPLT00000002060.2; ENSAPLP00000001486.2; ENSAPLG00000001913.2.
DR GeneTree; ENSGT00940000155119; -.
DR HOGENOM; CLU_000288_7_36_1; -.
DR OMA; CWAMSPD; -.
DR Proteomes; UP000016666; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR CDD; cd05043; PTK_Ryk; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..148
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 285..558
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 221..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 63133 MW; 767B438A6097D65C CRC64;
MCLNIQATSG AGGTESCFVV VWCCWVCPAL LLLSVFLSYV RNDVVNHYAL SFNLLIPSET
NNLHFSWHAK SKVEYKLGFQ VDNPMAMAMP QANISLQGEV PRTLSVFRVE LSCTGRLDSE
VTILMQLNLT INSSKNITVL NFKRRKMCYK KLEPEVKSPT SDKNSSKAIF DPVNAAPTTS
TRVFYISVGV CCAVIFLVAI ILAVLHLHSM KRIELDDSIS DSSSSQGLSQ PSTQTTQYLR
ADTPNNATPV TSYPTLRIEK NDLKSVTLME AKAKVKDIAI SRERITLKDV LQEGTFGRIF
HGILIEEKDP SKEKQVFVKT VKDQASEVQV TMMLTESCKL RGLHHRNLLP ITHVCIEEGE
KPMVLLPYMN WGNLKLFLRQ CKLVEANNPQ AISQQDLVHM AIQIACGMSY LARREVIHKD
LAARNCVIDD ALQVKITDNA LSRDLFPMDY HCLGDNENRP VRWMALESLV NNEFSSASDV
WAFGVTLWEL MTLGQTPYVD IDPFEMAAYL KDGYRIAQPI NCPDELFAVM ACCWALDPEE
RPKFQQLVQC LTEFHAALGA YV
//
