ID U3I3Q1_ANAPP Unreviewed; 828 AA.
AC U3I3Q1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=DENN domain containing 5A {ECO:0000313|Ensembl:ENSAPLP00000001872.2};
GN Name=DENND5A {ECO:0000313|Ensembl:ENSAPLP00000001872.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000001872.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000001872.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000001872.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3I3Q1; -.
DR STRING; 8840.ENSAPLP00000001872; -.
DR Ensembl; ENSAPLT00000002450.2; ENSAPLP00000001872.2; ENSAPLG00000002386.2.
DR GeneTree; ENSGT00940000153678; -.
DR HOGENOM; CLU_004201_2_0_1; -.
DR OMA; HYPENID; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 59..598
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 93944 MW; DADCC9F695526890 CRC64;
MIQFSAKSVT GNGQPPLSPA PLSRCSMSGG GGGGSSAPGR FADYFVICGL DTETGLEPDE
LSGENFEQTP LRRTFKSKVL ARYPENVEWN PFDQDAVGML CMPKGLAFKT QADSREPQFH
SFIITREDGS RTFGFSLTFF EEVTSKQICS AMQTLYHMHN AEYDILHTPP TNDKDSCSST
GDCNGTSVSK LQRFNSYDIS RDTLYVSKCI CLITPMSFMK ACKKVLEQLH QAVTSPQPPP
LPLESYIYNI LYEVPLPPAG RSLKFSGVYG PIICQRPSTN ELPLFDFPVK EVFELLGVEN
VVQLFTCALL EFQILLYSQH YQRLMTVAET ITALMFPFQW QHVYVPILPA SLLHFLDAPV
PYLMGLHSNG LDDRSKLELP QEANLCFVDI DNHFIELPED LPQFPNKLEF VQEISEILMA
FGIPPEGNLH CSESASKMKS LRACDLVSDK RNGNIAGSPL NSYELLKENE TIARLQALVK
RTGVSLEKVK ETSSKKDLKI QCDEEEFKVY QLNIQIREIF ANRFTQMFAD YEVFVIQPNQ
DKESWFTNRE QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDEDDKDPV
LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TIDEAEKSIE LRLAKIDHTA VHPHLLDMKI
GQGKYELGFF PKLQSDVLST GPASNKAVRI VLKQRYCFSI KRTNSKYIQE ARNLGSTIRQ
PKLSNLSPSV IAQTNWKFVE GLLKECRNKV IQRTYLFSCL LPDETEGNVL SFCKLTIRKT
WSGCEMVYPG WFCASCQLAA GDAGREMRRK DDSRSLRTLL VHNVLQGV
//
