ID U3I4E4_ANAPP Unreviewed; 505 AA.
AC U3I4E4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Lymphocyte activating 3 {ECO:0000313|Ensembl:ENSAPLP00000002115.2};
GN Name=LAG3 {ECO:0000313|Ensembl:ENSAPLP00000002115.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000002115.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000002115.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000002115.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; U3I4E4; -.
DR STRING; 8840.ENSAPLP00000002115; -.
DR Ensembl; ENSAPLT00000002700.2; ENSAPLP00000002115.2; ENSAPLG00000002679.2.
DR GeneTree; ENSGT01090000259985; -.
DR HOGENOM; CLU_041154_0_0_1; -.
DR OMA; HFVWSPL; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11422:SF7; LYMPHOCYTE ACTIVATING 3; 1.
DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..505
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019727488"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 145..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 329..412
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 505 AA; 54552 MW; D17525CC66A1F96B CRC64;
MRLVSLVLLL TFTLLVFSAG SILPGAAAGE QKVWAREGSS AMLPCYLSPR KQGRIWKQPS
DWTSVLWKRH GGSAHQEPHV VLEVEYTGLR KTALPMRPRV SVQDSALRSG NFSLRIDPVR
SGDAGLYEAQ VAYSTEVQSC QVELGIVTVT LSPPGPVVEG EPLLMSCNSS HRARLMETCW
FHNGRPVPTT KDFYSLHGAL SILQPSVSDS GSWHCQLRYS DNVVVSATHD LQILGFDGPA
NPVVYAAAGS AADLPCTLSY LPSAFGINAV AAHWSHLAGG HLQDWIISQN QSSRSFPLHL
PAVGPDDAGR YSCAVPVGSK TMRRDVTLAV VTVTPSIPGP ISEGSHLLLT CGVTHLQGHE
RFQWKLLSSA PTNKKGAMFT SHNLKDHRSQ TGRTLDISQV SQKDVGIWEC SVYGPEGRLG
AVEYGLQITG AQVSSPPTIF SGQVTFGLTV TLFFLLMVCI LALALQKRAR IPASYPALEG
IVAVAVPNKK DVEESQKETI QQTEC
//
