ID U3I5M9_ANAPP Unreviewed; 1021 AA.
AC U3I5M9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myosin IH {ECO:0000313|Ensembl:ENSAPLP00000002550.2};
GN Name=MYO1H {ECO:0000313|Ensembl:ENSAPLP00000002550.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000002550.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000002550.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000002550.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; U3I5M9; -.
DR Ensembl; ENSAPLT00000003140.2; ENSAPLP00000002550.2; ENSAPLG00000003020.2.
DR GeneTree; ENSGT00940000156430; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR Proteomes; UP000016666; Chromosome 16.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF353; UNCONVENTIONAL MYOSIN-IH; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 12..691
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 845..1018
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 568..590
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 105..112
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1021 AA; 117905 MW; 5C48A950D1EE6A0A CRC64;
MEGALIARDR VGVQDFVLLD SHTSETSFLN NLRKRYQENL IYTYIGTLLV SVNPYKELDI
YTVTQMQLYR GVNFFELPPH LYAIADNAYR VMCSEYNNHF ILISGESGAG KTEASKKILQ
YYAVTCPTTE QLQIVRDRLL LSNPVLEAFG NAKTLRNDNS SRFGKYMDIQ FDFKGAPVGG
HILSYLIEKS RVVHQNHGER NFHIFYQLLE GGDKDLLCWL GLERNPQKYA YLIQGRCAKV
FSINDKNDWK IVRKAFSIID FTEKDLEHLF GIVASVLHLG NIQFEEDSNG HAIIRNGTQI
KWISKLLGVH LSILQEALTH RKIEARSEEV LSPLNVDLAF YARDAVAKAI YGRTFTWLVN
KINGSLANKD STRKTVIGLL DIYGFEVLDT NSFEQFCINY CNEKLQQLLI EMTLKAEQEE
YELEGIEWEP IPYFNNKIIC DLVEQKHKGI ISILDEECLR PGEATDLSFL EKLEEKVGDH
AHFVTRKLAD QKTRKSIDWV DFRLLHYAGE VTYCAVGFLE KNNDLLYRNL KEVLCNSKNG
IIRDCFLLSE LDNRRRPETV ATQFKNSLMS LIEILMSKEP SYVRCIKPNE NKEPGKFDDF
LIRHQVKYLG LMEHLRVRRA GFAYRRKYEL FLQRYKSLCP ATWPHWHGPA AEGVERLIKH
LGYKPEEYKL GRTKIFIRFP KTLFATEDAF EIRKHLLVSR LQAKYKGCLG KREYQKKREA
AIKLEACWRG ALARKEAKKR TWAVQIIRKF INGFINRKKP LCPENIEFVR LVQYKYFMKL
RDHVPKNVLD KSWLRPPSIL EETSEMLKKI CIRNLVRKYC RGVTAERKVQ LQQKVVASAV
FRGKKEGYVQ SINQPFADTR LKENDINPKV LQLIQGEKIK YATPVVKYDR NGFKARERLL
VLTQSSAYVV EMAKIKQKID YATLKGISTS NLSDGIVVIH VPEDNKQKGD VILHCEHIFE
VVSKLCMLAN KQNLVKVVQG SLRFRIGSGK EGTMVFTVGQ ESQIFKAKNG QLTVVSTQAK
S
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